Evidence map›Paper›PMID 39373956›Full record

ReviewMolecular biotechnology2025

Advances in Metabolic Engineering for the Accumulation of Astaxanthin Biosynthesis.

Bingxin Yu, Tianyue Ma, Maryam Nawaz, Hailong Chen, Heng Zheng

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bingxin YuSchool of Life Science and Technology, China Pharmaceutical University, No. 639 Longmian Dadao, Jiangning District, Nanjing, 210009, People's Republic of China.
Tianyue MaSchool of Life Science and Technology, China Pharmaceutical University, No. 639 Longmian Dadao, Jiangning District, Nanjing, 210009, People's Republic of China.
Maryam NawazSchool of Life Science and Technology, China Pharmaceutical University, No. 639 Longmian Dadao, Jiangning District, Nanjing, 210009, People's Republic of China.
Hailong ChenSchool of Life Science and Technology, China Pharmaceutical University, No. 639 Longmian Dadao, Jiangning District, Nanjing, 210009, People's Republic of China.
Heng ZhengSchool of Life Science and Technology, China Pharmaceutical University, No. 639 Longmian Dadao, Jiangning District, Nanjing, 210009, People's Republic of China. zhengh18@hotmail.com.ORCID http://orcid.org/0009-0008-0663-4385

Funding

Priority Academic Program Development of Jiangsu Higher Education Institutions PAPD 2014065
6 · The paper itself

Abstract

Astaxanthin, a lipophilic carotenoid renowned for its strong antioxidant activity, holds significant commercial value across industries such as feed, food, and cosmetics. Although astaxanthin can be synthesized through chemical methods, it may contain toxic by-products in the synthesized astaxanthin, limiting its application in medicine or functional food. Natural astaxanthin can be extracted from algae, however, the cultivation cycle of algae is relatively longer compared to microorganisms. With the advancement of synthetic biology and metabolic engineering, the method of microbial fermentation has emerged as a promising strategy for the large-scale production of astaxanthin. This article provides a comprehensive overview of the research progress in astaxanthin biosynthesis, highlighting the use of the natural host Xanthophyllomyces dendrorhous, and the heterologous hosts Yarrowia lipolytica and Saccharomyces cerevisiae. Additionally, future research prospects are also discussed.

Indexed as

Metabolic EngineeringBasidiomycotaFermentationSaccharomyces cerevisiaeSynthetic BiologyXanthophyllsYarrowiaastaxanthineXanthophyllsAstaxanthinMetabolic engineeringSaccharomyces cerevisiaeXanthophyllomyces dendrorhousYarrowia lipolytica

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.