Evidence map›Paper›PMID 39373917›Full record

ArticleAnalytical and bioanalytical chemistry2024

Plasmonics-enhanced spikey nanorattle-based biosensor for direct SERS detection of mRNA cancer biomarkers.

Joy Q Li, Supriya Atta, Yuanhao Zhao, Khang Hoang, Aidan Canning, Pietro Strobbia, Julia E Canick, Jung-Hae Cho, Daniel J Rocke, Walter T Lee and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joy Q LiFitzpatrick Institute for Photonics, Duke University, Durham, NC, 27705, USA.
Supriya AttaFitzpatrick Institute for Photonics, Duke University, Durham, NC, 27705, USA.
Yuanhao ZhaoFitzpatrick Institute for Photonics, Duke University, Durham, NC, 27705, USA.
Khang HoangFitzpatrick Institute for Photonics, Duke University, Durham, NC, 27705, USA.
Aidan CanningFitzpatrick Institute for Photonics, Duke University, Durham, NC, 27705, USA.
Pietro StrobbiaFitzpatrick Institute for Photonics, Duke University, Durham, NC, 27705, USA.
Julia E CanickDepartment of Head and Neck Surgery & Communication Sciences, Duke School of Medicine, Durham, NC, 27710, USA.
Jung-Hae ChoFitzpatrick Institute for Photonics, Duke University, Durham, NC, 27705, USA.
Daniel J RockeDepartment of Head and Neck Surgery & Communication Sciences, Duke School of Medicine, Durham, NC, 27710, USA.
Walter T LeeDepartment of Head and Neck Surgery & Communication Sciences, Duke School of Medicine, Durham, NC, 27710, USA.
Tuan Vo-DinhFitzpatrick Institute for Photonics, Duke University, Durham, NC, 27705, USA. tuan.vodinh@duke.edu.

Funding

RAPID System for Early Detection of Head and Neck Cancer in Low-Resource SettingsR01DE030455 · NIDCR · DUKE UNIVERSITY · PI WALTER Tsong LEE, Tuan Vo-Dinh · 2022 to 2026
$2.7M
Integrated Acoustofluidic Plasmonic Molecular Diagnostic System for Detecting MicroRNA BiomarkersR01GM135486 · NIGMS · DUKE UNIVERSITY · PI VO-DINH, TUAN · 2020 to 2023
$1.8M
National Defense Science and Engineering Graduate Fellow ID: 00007902NIDCR NIH HHS 1R01DE030455-01A1NIDCR NIH HHS R01 DE030455NIGMS NIH HHS R01 GM135486NIGMS NIH HHS R01GM135486
6 · The paper itself

Abstract

We present a plasmonics-enhanced spikey nanorattle-based biosensor for direct surface-enhanced Raman scattering (SERS) detection of mRNA cancer biomarkers. Early detection of cancers such as head and neck squamous cell carcinoma (HNSCC) is critical for improving patient outcomes in regions with limited access to traditional diagnostic methods. Our method targets Keratin 14 (KRT14), a promising diagnostic mRNA biomarker for HNSCC, using a sandwich hybridization approach with magnetic beads and SERS spikey nanorattles (SpNR). We synthesized SpNR with a core-gap-shell structure to enhance SERS signals, achieving a limit of detection of 90 femtomolar. A pilot study using clinical samples demonstrated the efficacy of our biosensor in distinguishing between tissue with positive or negative diagnosis for HNSCC, highlighting its potential for rapid and sensitive cancer diagnostics in low-resource settings. This plasmonic assay offers a promising avenue for portable and high-specificity detection of nucleic acid biomarkers, with implications for early cancer detection and improved patient care, especially in middle and low-resource settings.

Indexed as

Biomarkers, TumorBiosensing TechniquesHead and Neck NeoplasmsRNA, MessengerSpectrum Analysis, RamanCarcinoma, Squamous CellHumansLimit of DetectionSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorRNA, MessengerBiomarkerBiosensormRNANanoparticlesPlasmonicsSERS

Identifiers

PMID39373917
PMCPMC11963791

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.