Evidence map›Paper›PMID 39373808›Full record

ArticleMolecular diversity2025

Design, synthesis, in vitro, and in silico study of benzothiazole-based compounds as a potent anti-Alzheimer agent.

Saquib Jalil, Ghulam Shabir, Aamer Saeed, Jamshed Iqbal

Abstract read
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In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Saquib JalilCentre for Advanced Drug Research, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
Ghulam ShabirDepartment of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan. shabirg@yahoo.com.
Aamer SaeedDepartment of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan. shabirg@yahoo.com.
Jamshed IqbalCentre for Advanced Drug Research, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a multifactorial neurological disorder that involves multiple enzymes in the process of developing. Conventional monotherapies provide relief, necessitating alternative multi-targeting approaches to address AD complexity. Therefore, we synthesize N-(benzo[d]thiazol-2-yl) benzamide-based compounds and tested against monoamine oxidases (MAO-A and MAO-B). In the in vitro experimental evaluation of MAO, all the compounds displayed remarkable potency, having IC

Indexed as

Alzheimer DiseaseBenzothiazolesDrug DesignMonoamine Oxidase InhibitorsComputer SimulationHumansKineticsMolecular Docking SimulationMolecular StructureMonoamine OxidaseStructure-Activity RelationshipBenzothiazolesMonoamine OxidaseMonoamine Oxidase InhibitorsAroyl isothiocyanatesBenzothiazolesContemporary spectroscopic techniquesDocking studiesMonoamine oxidase MAO-A and MAO-B inhibitors

Identifiers

PMID39373808

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.