Evidence map›Paper›PMID 39373780›Full record

ArticleJournal of neurology2024

Evaluating a motor progression connectivity model across Parkinson's disease stages.

Mallory L Hacker, David A Isaacs, Nanditha Rajamani, Kian Pazira, Eli Abdou, Sheffield Sharp, Thomas L Davis, Peter Hedera, Fenna T Phibbs, David Charles and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mallory L HackerDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. mallory.hacker@vumc.org.ORCID http://orcid.org/0000-0003-1498-4509
David A IsaacsDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Nanditha RajamaniMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität Zu Berlin, Berlin, Germany.
Kian PaziraDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Eli AbdouDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Sheffield SharpDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Thomas L DavisDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Peter HederaDepartment of Neurology, University of Louisville, Louisville, KY, USA.
Fenna T PhibbsDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
David Charles *Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Andreas Horn *Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität Zu Berlin, Berlin, Germany.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Computer-Assisted functional neurosurgeryR01EB006136 · NIBIB · VANDERBILT UNIVERSITY · PI DAWANT, BENOIT M. · 2006 to 2013
$4.0M
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1TR000445NCATS NIH HHS UL1 TR002243NIBIB NIH HHS R01 EB006136NIH HHS R01EB006136NIH HHS UL1TR000011
6 · The paper itself

Abstract

backgroundStimulation of a specific site in the dorsolateral subthalamic nucleus (STN) was recently associated with slower motor progression in Parkinson's Disease (PD), based on the deep brain stimulation (DBS) in early-stage PD pilot clinical trial. Here, subject-level visualizations are presented of this early-stage PD dataset to further describe the relationship between active contacts and motor progression. This study also evaluates whether stimulation of the sweet spot and connectivity model associated with slower motor progression is also associated with improvements in long-term motor outcomes in patients with advanced-stage PD.

methodsActive contacts of the early-stage PD cohort (N = 14) were analyzed alongside the degree of two-year motor progression. Sweet spot and connectivity models derived from the early-stage PD cohort were then used to determine how well they can estimate the variance in long-term motor outcomes in an independent STN-DBS cohort of advanced-stage PD patients (N = 29).

resultsIn early-stage PD, proximity of stimulation to the dorsolateral STN was associated with slower motor progression. In advanced-stage PD, stimulation proximity to the early PD connectivity model and sweet spot were associated with better long-term motor outcomes (R = 0.60, P < 0.001; R = 0.37, P = 0.046, respectively).

conclusionsResults suggest stimulation of a specific site in the dorsolateral STN is associated with both slower motor progression and long-term motor improvements in PD.

Indexed as

Deep Brain StimulationDisease ProgressionParkinson DiseaseSubthalamic NucleusAgedCohort StudiesFemaleHumansMaleMiddle AgedDeep brain stimulationMotor symptomsMovement disordersParkinson’s diseaseSubthalamic nucleus

Identifiers

PMID39373780
PMCPMC11561123

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.