Evidence map›Paper›PMID 39373526›Full record

ReviewJournal of leukocyte biology2025

Thymic stromal lymphopoietin signaling in B cells from progenitors to plasma cells.

Phillip P Domeier, Steven F Ziegler

Abstract readReview
In one paragraph

Review in Journal of leukocyte biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Phillip P DomeierCenter for Fundamental Immunology, Benaroya Research Institute, 1201 9th Avenue, Seattle, WA 98101, United States.ORCID 0000-0002-9937-8251
Steven F ZieglerCenter for Fundamental Immunology, Benaroya Research Institute, 1201 9th Avenue, Seattle, WA 98101, United States.ORCID 0000-0003-0657-5529

Funding

Regulation of Tfh function in autoimmunity by TSLPR21AI169418 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2022 to 2023
$476k
Regulation of germinal centers by thymic stromal lymphopoietin in mice and humansF32AI154787 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI DOMEIER, PHILLIP P · 2020 to 2022
$206k
NIAID NIH HHS F32 AI154787NIAID NIH HHS R21 AI169418NIH HHS F32AI154787
6 · The paper itself

Abstract

Thymic stromal lymphopoietin is an established pleotropic alarmin cytokine that is generated at barrier tissues to induce type 2 immune responses, but its role in regulating the diversity of B cells is poorly understood. Here, we will highlight the key findings that underpin our limited understanding of the role thymic stromal lymphopoietin in modulating different stages of B cell development. We will also provide an overview of how thymic stromal lymphopoietin drives B cell-mediated immune disease and how novel thymic stromal lymphopoietin-blocking biologics could be used to modulate B cell responses. Thymic stromal lymphopoietin is critical for the regulation, diversity, and longevity of humoral immunity.

Indexed as

B-LymphocytesCytokinesPlasma CellsSignal TransductionAnimalsCell DifferentiationHumansThymic Stromal LymphopoietinCytokinesThymic Stromal LymphopoietinB cellscytokinesthymic stromal lymphopoietin

Identifiers

PMID39373526
PMCPMC11878999

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.