Evidence map›Paper›PMID 39373362›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Biomimetic Scaffolds Regulating the Iron Homeostasis for Remolding Infected Osteogenic Microenvironment.

Mengting Yin, Zhiqing Liu, Zhongyi Sun, Xinyu Qu, Ziyan Chen, Yuying Diao, Yuxuan Cheng, Sisi Shen, Xiansong Wang, Zhuyun Cai and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mengting YinCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R China.
Zhiqing LiuCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R China.
Zhongyi SunCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R China.
Xinyu QuCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R China.
Ziyan ChenCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R China.
Yuying DiaoShanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 201102, P. R. China.
Yuxuan ChengCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R China.
Sisi ShenDepartment of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.
Xiansong WangDepartment of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.
Zhuyun CaiCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R China.
Bingqiang LuCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R China.
Shuo TanCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R China.
Yan WangShanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 201102, P. R. China.
Xinyu ZhaoCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R China.ORCID 0000-0002-1098-5670
Feng ChenCenter for Orthopaedic Science and Translational Medicine, Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R China.ORCID 0000-0002-1162-1684

Funding

National Key R&D Program of China 2022YFE0123500National Natural Science Foundation of China 31771081National Natural Science Foundation of China 32201102Science and Technology Commission of Shanghai Municipality 22S31903300Shanghai Municipal Health Commission 202140504Shanghai Pujiang Program 22PJD055
6 · The paper itself

Abstract

The treatment of infected bone defects (IBDs) needs simultaneous elimination of infection and acceleration of bone regeneration. One mechanism that hinders the regeneration of IBDs is the iron competition between pathogens and host cells, leading to an iron deficient microenvironment that impairs the innate immune responses. In this work, an in situ modification strategy is proposed for printing iron-active multifunctional scaffolds with iron homeostasis regulation ability for treating IBDs. As a proof-of-concept, ultralong hydroxyapatite (HA) nanowires are modified through in situ growth of a layer of iron gallate (FeGA) followed by incorporation in the poly(lactic-co-glycolic acid) (PLGA) matrix to print biomimetic PLGA based composite scaffolds containing FeGA modified HA nanowires (FeGA-HA@PLGA). The photothermal effect of FeGA endows the scaffolds with excellent antibacterial activity. The released iron ions from the FeGA-HA@PLGA help restore the iron homeostasis microenvironment, thereby promoting anti-inflammatory, angiogenesis and osteogenic differentiation. The transcriptomic analysis shows that FeGA-HA@PLGA scaffolds exert anti-inflammatory and pro-osteogenic differentiation by activating NF-κB, MAPK and PI3K-AKT signaling pathways. Animal experiments confirm the excellent bone repair performance of FeGA-HA@PLGA scaffolds for IBDs, suggesting the promising prospect of iron homeostasis regulation therapy in future clinical applications.

Indexed as

HomeostasisIronOsteogenesisTissue ScaffoldsAnimalsBiomimetic MaterialsBiomimeticsBone RegenerationCell DifferentiationDisease Models, AnimalMicePolylactic Acid-Polyglycolic Acid CopolymerIronPolylactic Acid-Polyglycolic Acid Copolymer3D printingantibacterial activitybone repairin situ growthiron homeostasis

Identifiers

PMID39373362
PMCPMC11600272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.