Evidence map›Paper›PMID 39372983›Full record

ArticleSurgical neurology international2024

A case of immunocompetent intracranial cryptococcoma in which intraoperative rapid pathological diagnosis and polymerase chain reaction led to early treatment: What to know to avoid misdiagnosis as brain tumor.

Saho Fujishita, Akihiro Inoue, Hideaki Watanabe, Masahiro Nishikawa, Mashio Taniwaki, Sayaka Matsumoto, Masayuki Ochi, Koichiro Suemori, Akira Watanabe, Riko Kitazawa and 3 more

Abstract readCase Reports
In one paragraph

Article in Surgical neurology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Saho FujishitaDepartment of Neurology and Geriatric Medicine, Ehime University School of Medicine, Toon, Ehime, Japan.
Akihiro InoueDepartment of Neurosurgery, Ehime University School of Medicine, Toon, Ehime, Japan.
Hideaki WatanabeDepartment of Neurosurgery, Ehime University School of Medicine, Toon, Ehime, Japan.
Masahiro NishikawaDepartment of Neurosurgery, Ehime University School of Medicine, Toon, Ehime, Japan.
Mashio TaniwakiDivision of Diagnostic Pathology, Ehime University School of Medicine, Toon, Ehime, Japan.
Sayaka MatsumotoDepartment of Neurology and Geriatric Medicine, Ehime University School of Medicine, Toon, Ehime, Japan.
Masayuki OchiDepartment of Neurology and Geriatric Medicine, Ehime University School of Medicine, Toon, Ehime, Japan.
Koichiro SuemoriDepartment of Hematology, Clinical Immunology and Infectious Diseases, Ehime University School of Medicine, Toon, Ehime, Japan.
Akira WatanabeMedical Mycology Research Center, Chiba University, Chiba, Japan.
Riko KitazawaDivision of Diagnostic Pathology, Ehime University School of Medicine, Toon, Ehime, Japan.
Seiji ShigekawaDepartment of Neurosurgery, Ehime University School of Medicine, Toon, Ehime, Japan.
Yasumasa OhyagiDepartment of Neurology and Geriatric Medicine, Ehime University School of Medicine, Toon, Ehime, Japan.
Takeharu KuniedaDepartment of Neurosurgery, Ehime University School of Medicine, Toon, Ehime, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cryptococcal infections of the central nervous system are infrequent in immunocompetent hosts and usually present as meningitis. However, a fungal mass called a cryptococcoma may form, requiring caution in therapeutic intervention. Here, we report a rare case in which treatment of intraventricular cryptococcoma in an immunocompetent patient was facilitated by rapid pathological diagnosis. Case Description: A 58-year-old previously healthy man was admitted to our hospital with fever, headache, and gradually worsening hearing loss over 1 month. Cerebrospinal fluid analysis showed moderately elevated levels of protein and lymphocytic cells and decreased glucose. In addition, β2-microglobulin was highly elevated. Magnetic resonance imaging showed homogeneously enhanced lesions in lateral ventricles of the left and right hemispheres and the subarachnoid space, and Conclusion: This pathology can be difficult to distinguish from a brain tumor, so early pathological diagnosis, including rapid pathology with IHC and PCR, may be crucial.

Indexed as

CryptococcomaCryptococcus neoformansFontana-Masson stainingPolymerase chain reactionRapid pathology

Identifiers

PMID39372983
PMCPMC11450775

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.