Evidence map›Paper›PMID 39372921›Full record

ArticleResearch square2024

α-Synuclein Conformations in Plasma Distinguish Parkinson's Disease from Dementia with Lewy Bodies.

George T Kannarkat, Rebecca Zack, R Tyler Skrinak, James F Morley, Roseanne Davila-Rivera, Sanaz Arezoumandan, Katherine Dorfmann, Kelvin Luk, David A Wolk, Daniel Weintraub and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

George T KannarkatDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.
Rebecca ZackDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.
R Tyler SkrinakDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.
James F MorleyDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.
Roseanne Davila-RiveraDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.
Sanaz ArezoumandanDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.
Katherine DorfmannDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.
Kelvin LukDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.ORCID 0000-0002-6591-6269
David A WolkDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.
Daniel WeintraubParkinson's Disease Research, Education and Clinical Center, Corporal Michael J. Crescenz VA Medical Center; Philadelphia, PA, USA, 19104.ORCID 0000-0003-0633-7168
Thomas F TropeaDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.ORCID 0000-0003-0766-1496
Edward B LeeDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.ORCID 0000-0002-4589-1180
Sharon X XieDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.
Ganesh ChandrasekaranDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.
Virginia M-Y LeeDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.ORCID 0000-0003-3536-6902
David IrwinDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.ORCID 0000-0002-5599-5098
Rizwan S AkhtarKen and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA, 60611.
Alice S Chen-PlotkinDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA, 19104.ORCID 0000-0002-3387-2038

Funding

Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Corey T McMillan · 2021 to 2026
$24.8M
Project IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9M
Understanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Lauren M Massimo · 2020 to 2026
$18.8M
NINDS Biomarker RepositoryU24NS095871 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI TATIANA M. FOROUD · 2015 to 2026
$18.3M
Project IV "Tackling Heterogeneity of Cognitive Trajectory in LBD"U19AG062418 · NIA · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2019 to 2023
$18.1M
Project IV: In Vivo Dissection of Genetic Modifiers on Different Stages of SynucleinopathyP01AG084497 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Kelvin C Luk · 2024 to 2026
$15.2M
TMEM106B in neurodegenerative diseaseR01NS082265 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CHEN-PLOTKIN, ALICE S · 2013 to 2024
$4.7M
Biomarkers of cognitive decline in Parkinson's DiseaseR01NS115139 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CHEN-PLOTKIN, ALICE S · 2019 to 2023
$3.6M
Remapping neurology through translation and innovationT32NS091008 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI AGUIRRE, GEOFFREY KARL, JENSEN, FRANCES E · 2015 to 2024
$3.0M
Understanding biomarkers of cognitive decline in Lewy body diseasesR37NS115139 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ALICE S CHEN-PLOTKIN · 2024 to 2026
$2.2M
The Role of Alzheimer's Disease Genetic Risk in Predicting Parkinson's Disease DementiaK23NS114167 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROPEA, THOMAS FRANCIS · 2020 to 2024
$985k
Alpha-synuclein biomarkers in Parkinson diseaseK08NS093127 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI AKHTAR, RIZWAN SMEER · 2015 to 2019
$918k
NIA NIH HHS P01 AG066597NIA NIH HHS P01 AG084497NIA NIH HHS P30 AG072979NIA NIH HHS U19 AG062418NINDS NIH HHS K08 NS093127NINDS NIH HHS K08 NS133286NINDS NIH HHS K23 NS114167NINDS NIH HHS P50 NS053488NINDS NIH HHS R01 NS082265NINDS NIH HHS R01 NS115139NINDS NIH HHS R37 NS115139NINDS NIH HHS T32 NS091008NINDS NIH HHS U24 NS095871
6 · The paper itself

Abstract

Aggregation of misfolded α-synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBD), including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Evidence exists for aSyn "strains" - conformations with distinct biological properties. However, biomarkers for PD vs. DLB, including potential aSyn strain differences, are lacking. Here, we used two monoclonal antibodies selective for different

Identifiers

PMID39372921
PMCPMC11451739

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.