Evidence map›Paper›PMID 39372873›Full record

ArticleFrontiers in oncology2024

Transoral laser microsurgery for supraglottic carcinomas: results of a prospective multicenter trial (SUPRATOL).

Petra Ambrosch, Sylvia Meuret, Andreas Dietz, Asita Fazel, Rainer Fietkau, Ralf Tostmann, Ursula Schroeder, Anne Lammert, Julian Künzel, Martin C Jäckel and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Oncologic parity in T2 laryngeal cancer: transoral laser surgery and open partial laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Petra Ambrosch *Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Schleswig-Holstein (UKSH), University of Kiel, Kiel, Germany.
Sylvia Meuret *Section of Phoniatrics and Audiology, Clinic of Otorhinolaryngology, University of Leipzig, Leipzig, Germany.
Andreas DietzClinic of Otorhinolaryngology, University of Leipzig, Leipzig, Germany.
Asita FazelDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Schleswig-Holstein (UKSH), University of Kiel, Kiel, Germany.
Rainer FietkauDepartment of Radiooncology, Friedrich-Alexander-University, Erlangen-Nuremberg, Erlangen, Germany.
Ralf TostmannClinical Trial Unit UMG, Universitätsmedizin Goettingen, Goettingen, Germany.
Ursula SchroederDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Schleswig-Holstein (UKSH), University of Luebeck, Luebeck, Germany.
Anne LammertDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty Mannheim, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany.
Julian KünzelDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Regensburg, Regensburg, Germany.
Martin C JäckelDepartment of Otorhinolaryngology, Helios-Kliniken Schwerin, Schwerin, Germany.
Daniel BoegerDepartment of Otorhinolaryngology, SRH Zentralklinikum Suhl, Suhl, Germany.
Claudia ScherlDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty Mannheim, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany.
Thomas DeitmerGerman Society of Otorhinolaryngology, Head and Neck Surgery (DGHNO-KHC), Bonn, Germany.
Kerstin BreitensteinDepartment of Otorhinolaryngology, Helios-Klinikum Erfurt, Erfurt, Germany.
K-Wolfgang DelankDepartment of Otorhinolaryngology, Head and Neck Surgery, Klinikum der Stadt Ludwigshafen gGmbH, Ludwigshafen, Germany.
Hermann HilberDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Regensburg and Private Medical Practice for Otorhinolaryngology, Regensburg, Germany.
Sarah VesterDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Regensburg, Regensburg, Germany.
Stephan KnippingDepartment of Otorhinolaryngology, Head and Neck Surgery, Städtisches Klinikum Dessau, Dessau, Germany.
Ulrich HarreusDepartment of Otorhinolaryngology, Krankenhaus Bad Tölz, Bad Tölz, Germany.
Matthias ScheichDepartment of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius-Maximilians-University Hospital Würzburg, Würzburg, Germany.
Sylva BartelDepartment of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, Halle, Germany.
Stefan K PlontkeDepartment of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, Halle, Germany.
Sven KoscielnyDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Jena, Jena, Germany.
Johannes A VeitDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty Mannheim, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany.
Jens GreveDepartment of Otorhinolaryngology, Head and Neck Surgery, Ulm University Hospital, Ulm, Germany.
Volker SchillingDepartment of Otorhinolaryngology, Head and Neck Surgery, Vivantes Klinikum Neukölln, Germany.
Maximilian LinxweilerDepartment of Otorhinolaryngology, Saarland University, Homburg, Germany.
Sonja WeißDepartment of Otorhinolaryngology, Klinikum Kassel, Kassel, Germany.
Georgios PsychogiosClinic of Otorhinolaryngology, University of Ioannina, Ioannina, Greece.
Christoph ArensDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Giessen, Germany.
Claus WittekindtDepartment of Otorhinolaryngology, Head and Neck Surgery, Klinikum Dortmund, Dortmund, Germany.
Jens OekenDepartment of Otorhinolaryngology, Hospital Chemnitz, Chemnitz, Germany.
Maria GroshevaDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
Christoph BorzikowskyInstitute of Medical Informatics and Statistics, Christian-Albrechts-University Kiel, Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A limited number of single institutions have published retrospective cohort studies on transoral laser microsurgery for supraglottic laryngectomy (TLM-SGL). These studies have shown that the oncologic outcomes of TLM-SGL are comparable to those of open SGL. However, there is limited information available regarding swallowing rehabilitation and quality of life (QoL). Patients and methods: SUPRATOL is a prospective, multicenter trial assessing the functional outcomes of TLM-SGL +/- adjuvant radio-(chemo)-therapy. The primary endpoint was aspiration-free swallowing at 12 months, as established using fibreoptic endoscopic evaluation of swallowing (FEES) and defined as a grade < 6 on the penetration-aspiration scale. Secondary endpoints were swallowing- and voice-related QoL, the prevalence of temporary and permanent tracheostomy and percutaneous gastrostomy, local control, laryngectomy-free survival, overall survival, and disease-free survival, as well as the influence of treatment centers on outcomes. Results: From April 2015 to February 2018, 102 patients were recruited from 26 German Otorhinolaryngology (ORL) hospitals. All patients had TLM-SGL and 96.1% underwent uni- or bilateral, mostly selective neck dissection. To 47.0% of patients, adjuvant radio-(chemo)-therapy (R(C)T) was administered. The median follow-up period was 24.1 months. At 12-month follow-up, completed by 84.3% of patients, 98.2%, 95.5%, and 98.8% were free of aspiration when tested with saliva, liquid, or pulp. Adjuvant R(C)T, pT category, and type of resection had no significant influence on swallowing rehabilitation. A total of 40.2% of patients had been tracheotomized, and in 46.1% of patients, a PEG tube was inserted. At the 24-month follow-up, 5.3% of patients still required a tracheostomy, and 8.0% continued to use a percutaneous endoscopic gastrostomy (PEG) tube. Deterioration of swallowing- and voice-related QoL was observed immediately after treatment, but patients recovered, and baseline values were reached again. The Kaplan-Meier 2-year rates for local control, laryngectomy-free survival, overall survival, and disease-free survival were 88%, 92%, 93%, and 82%, respectively. Conclusions: Our prospective multicenter trial shows that, at 12 months post-TLM-SGL +/- R(C)T, 95.5%-98.8% of patients achieved aspiration-free swallowing. Morbidity was higher than previously reported. The rates of permanent tracheostomy and gastrostomy tube placement correspond to previous cohort studies. The 2-year oncologic outcomes are within the reported range. Clinical trial registration: https://drks.de/search/en/trial/DRKS00004641, identifier (DRKS00004641).

Indexed as

FEESfunctional outcomesMDADIprospective multicenter trialsupraglottic carcinomatransoral laser microsurgeryVHI

Identifiers

PMID39372873
PMCPMC11449847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.