Evidence map›Paper›PMID 39372701›Full record

ArticleFrontiers in neurology2024

A dietary intervention with conjugated linoleic acid enhances microstructural white matter reorganization in experimental stroke.

Frederike A Straeten, Jan-Kolja Strecker, Anna-Lena Börsch, Bastian Maus, Maike Hoppen, Birgit Schmeddes, Lucia Härtel, Ann-Katrin Fleck, Stephanie van Zyl, Tabea Straeten and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Frederike A StraetenDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Jan-Kolja StreckerDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Anna-Lena BörschDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Bastian MausTranslational Research Imaging Center, University of Münster, Münster, Germany.
Maike HoppenDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Birgit SchmeddesDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Lucia HärtelDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Ann-Katrin FleckDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Stephanie van ZylDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Tabea StraetenDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Carolin BeukerDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Mailin KoeckeDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Louisa Mueller-MinyDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Cornelius FaberTranslational Research Imaging Center, University of Münster, Münster, Germany.
Gerd Meyer Zu HörsteDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Luisa KlotzDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Jens MinnerupDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.
Antje Schmidt-PogodaDepartment of Neurology, University Hospital Münster, University of Münster, Münster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A dietary supplementation with conjugated linoleic acid (CLA) was shown to attenuate inflammation and increase the proportions of circulating regulatory T cells (T Methods: Functional assessment was performed over 90 days after induction of experimental photothrombotic stroke in wild type mice ( Results: MR diffusion tensor imaging (DTI) demonstrated enhanced microstructural reorganization of interhemispheric white matter tracts, dependent on lesion size. Functional recovery over 90 days remained unaffected. Detailed immunological analyses across various compartments revealed no significant long-term immunological alterations due to CLA. However, analyses of human blood samples post-stroke showed reduced levels of pro-inflammatory interferon-γ (IFN-γ) and tumor necrosis factor alpha (TNF-α) release by T-lymphocytes following Conclusion: We aimed to explore the efficacy of a dietary intervention with minimal known side effects that could be accessible to human stroke patients, regardless of the degree of disability, and without the risks associated with aggressive immunomodulatory therapies. Our main findings include improved microstructural reorganization in small infarcts and a reduced inflammatory response of human T cells

Indexed as

conjugated linoleic acid (CLA)functional recoveryischemic strokeMRIstroke neuroinflammation

Identifiers

PMID39372701
PMCPMC11449868

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.