Evidence map›Paper›PMID 39372681›Full record

ArticleStem cells international2024

Shh Signaling from the Injured Lung Microenvironment Drives BMSCs Differentiation into Alveolar Type II Cells for Acute Lung Injury Treatment in Mice.

Mengyu Wu, Jing Liu, Shu Zhang, Yi Jian, Ling Guo, Huacai Zhang, Junwei Mi, Guoxin Qu, Yaojun Liu, Chu Gao and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mengyu Wu *Department of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Jing Liu *Department of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Shu ZhangDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Yi JianDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Ling GuoDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Huacai ZhangDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Junwei MiDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Guoxin QuDepartment of Orthopedic Surgery The First Affiliated Hospital of Hainan Medical University, Haikou 570100, Hainan Province, China.
Yaojun LiuDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Chu GaoDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Qingli CaiDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Dalin WenDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Di LiuDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Jianhui SunDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.
Jianxin JiangDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.ORCID https://orcid.org/0000-0002-2945-1134
Hong HuangDepartment of Trauma Medical Center Daping Hospital State Key Laboratory of Trauma and Chemical Poisoning Army Medical University, Chongqing 400042, China.ORCID https://orcid.org/0000-0001-7688-3506

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alveolar type II (AT2) cells are key effector cells for repairing damaged lungs. Direct differentiation into AT2 cells from bone marrow mesenchymal stem cells (BMSCs) is a promising approach to treating acute lung injury (ALI). The mechanisms of BMSC differentiation into AT2 cells have not been determined. The Sonic Hedgehog (Shh) pathway is involved in regulating multiple differentiation of MSCs. However, the role of the Shh pathway in mediating the differentiation of BMSCs into AT2 cells remains to be explored. The results showed that BMSCs significantly ameliorated lung injury and improved pulmonary function in mice with ALI. These improvements were accompanied by a relatively high proportion of BMSCs differentiate into AT2 cells and an increase in the total number of AT2 cells in the lungs. Lung tissue extracts from mice with ALI (ALITEs) were used to mimic the injured lung microenvironment. The addition of ALITEs significantly improved the differentiation efficiency of BMSCs into AT2 cells along with activation of the Shh pathway. The inhibition of the Shh pathway not only reduced the differentiation rate of BMSCs but also failed to mitigate lung injury and regenerate AT2 cells. The results confirmed that promoting AT2 cell regeneration through the differentiation of BMSCs into AT2 cells is one of the important therapeutic mechanisms for the treatment of ALI with BMSCs. This differentiation process is highly dependent on Shh pathway activation in BMSCs in the injured lung microenvironment.

Identifiers

PMID39372681
PMCPMC11455595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.