ArticleFrontiers in aging neuroscience2024
Prolonged moderate to vigorous physical activity may lead to a decline in cognitive performance: a Mendelian randomization study.
Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial.European stroke journal · 2026Trial
- Association of physical activity with incident dementia and cognitive decline among Australian older adults.GeroScience · 2026Article
- Hippocampal Glutamatergic Hyperactivation Mediates High-Loading Intensity of Exercise-Induced Cognitive Deficits Via HPC-mPFC Circuit Dysfunction.CNS neuroscience & therapeutics · 2026Article
- Joint effects of sleep behaviors and physical activity on brain structure and cognitive function.Fundamental research · 2026Article
- Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial.European stroke journal · 2025Article
- The association between sports social capital and cognitive health: A longitudinal study of middle-aged and elderly adults in China.SSM - population health · 2025Article
- The impact of physical activities on cognitive function among older adult populations: evidence from China.Frontiers in public health · 2025Article
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Authors and funding
5 authors.
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Abstract
Objective: This study investigates the causal relationship between moderate to vigorous physical activity and cognitive performance. Methods: Genetic loci strongly related to moderate to vigorous physical activity from genome-wide association studies were used as instrumental variables. These were combined with genetic data on cognitive performance from different Genome-Wide Association Study (GWAS) to conduct a two-sample Mendelian randomization analysis. The primary analysis used inverse variance weighting within a random effects model, supplemented by weighted median estimation, MR-Egger regression and other methods, with results expressed as Beta coefficient. Results: This study selected 19 SNPs closely related to physical activity as instrumental variables. The multiplicative random-effects Inverse-Variance Weighted (IVW) analysis revealed that moderate to vigorous physical activity was negatively associated with cognitive performance (Beta = -0.551; OR = 0.58; 95% CI: 0.46-0.72; Conclusion: The findings of this study indicate that genetically predicted moderate to vigorous physical activity may be associated with a decline in cognitive performance.
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