ArticleFrontiers in microbiology2024
Diagnostic values of BALF metagenomic next-generation sequencing, BALF real-time PCR and serum BDG for
Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A diagnostic model for discrimination between Pneumocystis jirovecii pneumonia and colonization based on multiple parameters.Scientific reports · 2026Article
- Performance Characteristics of Real-Time Quantitative PCR and Cycle Threshold (Ct) Values for the Diagnosis ofInfection and drug resistance · 2026Article
- Diagnostic performance and clinical utility of metagenomic next-generation sequencing in suspected pulmonary infections: a comparative study stratified by immune status.Frontiers in cellular and infection microbiology · 2026Article
- Clinical Impact of Polymicrobial Interactions in Human-Metapneumovirus-Infected Children: A Targeted Next-Generation Sequencing Based Retrospective Study.Infection and drug resistance · 2026Article
- Advances in pathogen detection ofInfectious medicine · 2025Review
- Clinical characteristics ofJournal of thoracic disease · 2025Article
- Epidemiology of and Risk Factors Associated with Mortality from Invasive Pulmonary Fungal Infection in Non-Neutropenic Patients in China: A 10-Year Retrospective Study.The American journal of tropical medicine and hygiene · 2025Article
- [An infant with leukemia complicated byZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Impact of cytomegalovirus DNAemia detected by next-generation sequencing on short-term prognosis after lung transplantation.Infectious medicine · 2025Article
- Clinical Value of Metagenomic Next-Generation Sequencing From Blood Samples to IdentifyOpen forum infectious diseases · 2025Article
- Effect of BALF-based mNGS on clinical outcomes of immunocompromised subjects with opportunistic pulmonary infections: a multicenter propensity score-matched study.Frontiers in cellular and infection microbiology · 2025Article
- Analysis of microorganisms and drug-resistance mutations detected by probe-capture metagenomics among HIV-infected patients with pneumonia.Frontiers in microbiology · 2025Article
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12 authors.
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Abstract
Introduction: This study aimed to assess the diagnostic values of bronchoalveolar lavage fluid (BALF) real-time polymerase chain reaction (PCR) and BALF metagenomic next-generation sequencing (mNGS) for Pneumocystis jirovecii pneumonia (PJP) in patients infected with human immunodeficiency virus (HIV). Methods: A total of 99 HIV-infected PJP patients and 61 HIV-infected patients diagnosed with non-PJP pneumonia between March 2019 and December 2022 were enrolled. Results: The sensitivity of mNGS test of BALF samples reached 85.86%, which was significantly higher than serum BDG (39.39%, Conclusion: BALF mNGS and real-time PCR are two powerful techniques for rapid diagnosis of PJP with high specificity and sensitivity. Moreover, the benefit of mNGS is that it may identify other organisms besides PJP and it may benefit proper and prompt treatment.
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