ArticleJACC. Asia2024
Bidirectional Associations Between Cardiometabolic Multimorbidity and Depression and Mediation of Lifestyles: A Multicohort Study.
Article in JACC. Asia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multimorbidity and the risk of depression: a systematic review of cohort studies.Journal of global health · 2026Pooled it
- Joint Trajectories of Physical Activity and Depressive Symptoms and Incident Cardiometabolic Multimorbidity: A Multi-Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Physical frailty, depression and multimorbidity among older adults in Lima, Peru: a cross-sectional study.BMC geriatrics · 2026Article
- Association of air pollution and depressive symptoms with cardiometabolic Multimorbidity in middle-aged and older adults: an analysis based on the China health and retirement longitudinal study (CHARLS).Acta diabetologica · 2026Article
- Habitual Tea Consumption Is Associated with a Low Prevalence of Self-Reported Lifetime History of Depression in Taiwanese Population Study.Nutrients · 2026Article
- Change in loneliness and subsequent cardiometabolic Multimorbidity among middle-aged and older adults: results from two east asian prospective cohorts.Aging clinical and experimental research · 2026Article
- Article
- Effect Heterogeneity of CPAP on MACE by Nocturnal Hypoxia Burden in Older Adults OSAS: A Propensity Score Matching Study.Clinical interventions in aging · 2026Article
- External factors show reproducible local symptom-biomarker associations in middle-aged and older adults with heart disease.Frontiers in psychiatry · 2026Article
- Sleep duration, sleep quality, and daytime napping in relation to incident cardiometabolic multimorbidity across three national aging cohorts: a prospective, interpretable machine learning study.Frontiers in nutrition · 2026Article
- Physical-psychological-cognitive multimorbidity: a narrative review.Frontiers in public health · 2026Review
- A Systematic Review and Meta-analysis of the Global Prevalence of Depression in Older Adults with Multi-morbidity.Indian journal of psychological medicine · 2025Review
- Associations of life course social determinants of health, social mobility with cognitive function and roles of social participation and lifestyle: a multicohort study.BMC medicine · 2025Article
- Risk prediction of cardiometabolic diseases with depression in the community of Xinjiang production and construction corps.BMC public health · 2025Article
- Article
- Spatial heterogeneity and its influencing factors of cardiometabolic multimorbidity in a natural community population: a study based on Lingwu city, rural Northwest China.BMC public health · 2025Article
- Obesity-depression-metabolism triad: amplification of cardiometabolic multimorbidity risk in Chinese adults (CHARLS 2011-2018).Lipids in health and disease · 2025Article
- Association between sensory impairment and cardiometabolic multimorbidity among older Chinese adults: a cross-sectional study based on the China Health and Retirement Longitudinal Study.BMC geriatrics · 2025Article
- Multimorbidity Patterns and Depression: Bridging Epidemiological Associations with Predictive Analytics for Risk Stratification.Healthcare (Basel, Switzerland) · 2025Article
- Linking cardiometabolic multimorbidity to depressive symptoms in the oldest-old: results from a cross-sectional study in Germany.BMC public health · 2025Article
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7 authors.
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Abstract
Background: Cardiometabolic multimorbidity (CMM) and depression are major health concerns, and the onset of either condition may heighten the risk of developing the other. Objectives: The goal of this study was to characterize the reciprocal associations between CMM and depression among middle-aged and older adults. Methods: This multicohort study used harmonized data from 5 prospective cohorts from China, South Korea, the United States, the United Kingdom, and Europe. Cardiometabolic diseases (CMDs) (including diabetes, heart diseases, and stroke) and depression were assessed at baseline and at 7 to 8 years' follow-up. Lifestyle factors, including physical activity, alcohol consumption, and smoking status, were regarded as potential mediators. Two sets of analyses, CMM-depression analyses (n = 67,188) and depression-CMM analyses (n = 65,738), were conducted to explore the bidirectional associations between CMM and depression. Results: In the CMM-depression analyses, 16,596 (24.7%) individuals developed depression. Participants with a single CMD (HR: 1.24; 95% CI:1.19-1.29) and CMM (HR: 1.52; 95% CI: 1.42-1.63) at baseline had higher risks of depression occurring. Physical activity and alcohol consumption significantly mediated 7.5% and 6.9% of the CMM-depression association, respectively. In the depression-CMM analyses, 1,461 (2.2%) participants developed CMM. The HR for developing CMM was 1.31 (95% CI: 1.14-1.50) in patients with depression, with increased risk of developing more CMDs. Physical activity and alcohol consumption mediated 12.0% and 7.1% of the depression-CMM association. The bidirectional relationships were more pronounced in Western countries than in Asian countries. Conclusions: CMM and depression were bidirectionally associated. The mediated effects of lifestyle factors were larger in the depression-lifestyle-CMM pathway than in the CMM-lifestyle-depression pathway.
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