Evidence map›Paper›PMID 39371473›Full record

ArticleProceedings. IEEE International Symposium on Biomedical Imaging2024

BOOSTING SKULL-STRIPPING PERFORMANCE FOR PEDIATRIC BRAIN IMAGES.

William Kelley, Nathan Ngo, Adrian V Dalca, Bruce Fischl, Lilla Zöllei, Malte Hoffmann

Abstract read
In one paragraph

Article in Proceedings. IEEE International Symposium on Biomedical Imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
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  5. Deep infant brain segmentation from multi-contrast MRI.Conference record. Asilomar Conference on Signals, Systems & Computers · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. MultiMorph: On-demand Atlas Construction.Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · 2025
    Article
  11. Article
  12. Synthetic data in generalizable, learning-based neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

William KelleyAthinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA.
Nathan NgoAthinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA.
Adrian V DalcaAthinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA.
Bruce FischlAthinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA.
Lilla ZölleiAthinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA.
Malte HoffmannAthinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA.

Funding

BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
The Human Connectome Project (HCP)U01MH093765 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2010 to 2014
$12.1M
Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang · 2020 to 2026
$10.9M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain Admin SupplementU01MH117023 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A, FISCHL, BRUCE · 2018 to 2022
$7.6M
FreeSurfer Development, Maintenance, and HardeningR01EB023281 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl, Douglas Nowlin Greve · 2016 to 2026
$5.6M
A Longitudinal Analysis Stream for FreeSurferR01NS083534 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2014 to 2026
$4.6M
BRAIN CONNECTS: Mapping Connectivity of the Human Brainstem in a Nuclear Coordinate SystemU01NS132181 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE, HOF, PATRICK R · 2023 to 2025
$4.2M
Brainstem Arousal Network in Human Consciousness: Healthy development vs SIDSR01HD102616 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI Lilla Zollei · 2021 to 2026
$3.5M
Segmenting Brain Structures for Neurological DisordersR01NS105820 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2019 to 2026
$3.2M
Neuroimaging and gut microbiome markers of development in HIV-exposed uninfected infantsR01HD093578 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI HOLMES, MARTHA, KABA, MAMADOU · 2017 to 2022
$2.9M
NCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG070988NIA NIH HHS R21 AG082082NIA NIH HHS R56 AG064027NIBIB NIH HHS P41 EB015896NIBIB NIH HHS P41 EB030006NIBIB NIH HHS R01 EB019956NIBIB NIH HHS R01 EB023281NIBIB NIH HHS R01 EB033773NIBIB NIH HHS R21 EB018907NICHD NIH HHS R00 HD101553NICHD NIH HHS R01 HD085813NICHD NIH HHS R01 HD093578NICHD NIH HHS R01 HD102616NICHD NIH HHS R01 HD109436NICHD NIH HHS R21 HD106038NIMH NIH HHS RF1 MH121885NIMH NIH HHS RF1 MH123195NIMH NIH HHS U01 MH093765NIMH NIH HHS U01 MH117023NINDS NIH HHS R01 NS070963NINDS NIH HHS R01 NS083534NINDS NIH HHS R01 NS105820NINDS NIH HHS U01 NS132181NINDS NIH HHS UM1 NS132358
6 · The paper itself

Abstract

Skull-stripping is the removal of background and non-brain anatomical features from brain images. While many skull-stripping tools exist, few target pediatric populations. With the emergence of multi-institutional pediatric data acquisition efforts to broaden the understanding of perinatal brain development, it is essential to develop robust and well-tested tools ready for the relevant data processing. However, the broad range of neuroanatomical variation in the developing brain, combined with additional challenges such as high motion levels, as well as shoulder and chest signal in the images, leaves many adult-specific tools ill-suited for pediatric skull-stripping. Building on an existing framework for robust and accurate skull-stripping, we propose developmental SynthStrip (d-SynthStrip), a skull-stripping model tailored to pediatric images. This framework exposes networks to highly variable images synthesized from label maps. Our model substantially outperforms pediatric baselines across scan types and age cohorts. In addition, the <1-minute runtime of our tool compares favorably to the fastest baselines. We distribute our model at https://w3id.org/synthstrip.

Indexed as

brain extractioninfantmachine learningnewbornpediatric MRIskull-strippingtoddler

Identifiers

PMID39371473
PMCPMC11451993

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.