Evidence map›Paper›PMID 39371169›Full record

ArticlemedRxiv : the preprint server for health sciences2024

First imported Cases of MPXV Clade Ib in Goma, Democratic Republic of the Congo: Implications for Global Surveillance and Transmission Dynamics.

Daniel Mukadi-Bamuleka, Eddy Kinganda-Lusamaki, Noella Mulopo-Mukanya, Adrienne Amuri-Aziza, Áine O'Toole, Brigitte Modadra-Madakpa, Guy Mutombo Ndongala, Emmanuel Hasivirwe Vakaniaki, Sydney Merritt, Cris Kacita and 43 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

53 authors.

Daniel Mukadi-BamulekaService de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.
Eddy Kinganda-LusamakiService de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.
Noella Mulopo-MukanyaRodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo.
Adrienne Amuri-AzizaInstitut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Áine O'TooleInstitute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK.
Brigitte Modadra-MadakpaRodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo.
Guy Mutombo NdongalaProvincial Health Division, North Kivu, Democratic Republic of the Congo.
Emmanuel Hasivirwe VakaniakiInstitut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Sydney MerrittDepartment of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, California, USA.ORCID 0000-0002-4039-605X
Cris KacitaHemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa, Democratic Republic of the Congo.
Gaston Lubambo MabokoProvincial Health Division, North Kivu, Democratic Republic of the Congo.
Jean-Claude Makangara-CigoloService de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.
Michel NgimbaRodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo.
Emmanuel LokiloInstitut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Elisabeth Pukuta-SimbuInstitut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Gradi LuakandaInstitut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Tavia Bodisa-MatamuRodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo.
Zephanie Paluku KalimuliRodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo.
Prince Akil-BandaliInstitut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Sifa KaviraInstitut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Daan JansenDepartment of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Adèle Kavira KamaliroInstitut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Emile Muhindo-MilondeInstitut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Jeriel MufungiziRodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo.
Yves Birindwa HamisiRodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo.
Hugo KavungaRodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo.
Olivier TshianiInstitut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Sabin S NunduInstitut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo.
Laurens LiesenborghsDepartment of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.ORCID 0000-0001-5616-8548
Nicole A HoffDepartment of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, California, USA.
Jean NachegaDepartment of Epidemiology, Infectious Diseases and Microbiology, University of Pittsburgh, School of Public Health, Pittsburgh, Pennsylvania, USA.
Robert ShongoHemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa, Democratic Republic of the Congo.
Ahidjo AyoubaTransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier, Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), Montpellier, France.
Genay PilarowskiChan Zuckerberg Biohub, San Francisco, California, USA.
Alain Kakule MangolopaWorld Health Organization, Geneva, Switzerland.
Amos Kiuka EbondoWorld Health Organization, Geneva, Switzerland.
Nicola LowUniversity of Bern, Bern, Switzerland.
Souradet Y ShawCommunity Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Sam WilkinsonUniversity of Birmingham, Birmingham, UK.ORCID 0000-0002-6944-5927
Sofonias Kifle TessemaAfrica Centres for Disease Control and Prevention, Addis Ababa, Ethiopia.
Lorenzo SubissiWorld Health Organization, Geneva, Switzerland.
Eric DelaporteTransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier, Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), Montpellier, France.
Koen VercauterenDepartment of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Tony Wawina-BokalangaService de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.
Anne W RimoinDepartment of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, California, USA.
Martine PeetersTransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier, Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), Montpellier, France.
Nicholas LomanUniversity of Birmingham, Birmingham, UK.
Andrew RambautTransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier, Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), Montpellier, France.
Jean-Jacques Muyembe-TamfumService de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.
Lisa E HensleyUS Department of Agriculture, Agricultural Research Service, Manhattan, Kansas, USA.
Jason KindrachukDepartment of Medical Microbiology & Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Internal Medicine, University of Manitoba, Canada.ORCID 0000-0002-3305-7084
Placide Mbala-KingebeniService de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.
Steve Ahuka-MundekeService de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa.

Funding

Emerging Infectious Diseases Research Center - East and Central AfricaU01AI151799 · NIAID · WASHINGTON STATE UNIVERSITY · PI M KARIUKI NJENGA · 2020 to 2026
$10.4M
NIAID NIH HHS U01 AI151799Wellcome Trust
6 · The paper itself

Abstract

The ongoing national mpox outbreak in the Democratic Republic of the Congo has resulted in more >30,000 suspected cases in the country from January 2023 to August 2024. While these historic case totals have been driven by primarily by zoonosis, the emergence of Clade Ib monkeypox virus (MPXV), which is connected to more sustained human-to-human transmission, has been associated with increasing public health impacts in eastern DRC. First identified in South Kivu province, Clade Ib MPXV has been identified in multiple non-endemic East African countries for the first time. In DRC, there have been concerns over broader Clade Ib expansion in the country that could further complicate containment and mitigation responses. Here, we report the first introductions of Clade Ib into North Kivu province, including within internal displacement camps, with suspected close contact transmission that includes non-intimate contacts and children. These findings demonstrate that mpox case investigations and community messaging campaigns should include considerations for non-sexual contact-mediated transmission of Clade Ib that includes children <15 years.

Indexed as

cross-border transmissionepidemic spreadGomaMonkeypox virusMpoxphylogeneticssexual transmission

Identifiers

PMID39371169
PMCPMC11451630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.