Evidence map›Paper›PMID 39371162›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Assessment of common genetic variation in Alzheimer's and Parkinson's diseases reveals global distinction in population attributable risk.

Lietsel Jones, Catalina Cerquera-Cleves, Artur Fs Schuh, Mary B Makarious, Hirotaka Iwaki, Mike A Nalls, Alastair J Noyce, Global Parkinson’s Genetics Program (GP2), Cornelis Blauwendraat, Andrew Singleton and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lietsel JonesCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5293-0654
Catalina Cerquera-ClevesDepartment of Neurosciences, Neurology Unit, Hospital Universitario San Ignacio, Bogotá, Colombia.
Artur Fs SchuhDepartamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID 0000-0002-8722-0908
Mary B MakariousCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Hirotaka IwakiCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Mike A NallsCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Alastair J NoyceCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Global Parkinson’s Genetics Program (GP2)
Cornelis BlauwendraatCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Andrew SingletonCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Ignacio MataGenomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.ORCID 0000-0003-1198-0633
Mark R CooksonCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1058-3831
Sara Bandres-CigaCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Funding

Harmonized Data-Derived Resources for the Alzheimer's Disease and Related Dementias CommunityZIAAG000534 · NIA · NATIONAL INSTITUTE ON AGING · PI COOKSON, MARK · 2019 to 2025
$85.1M
The Interplay between Genetics and Aerobic Exercise to Slow Parkinson's disease (GEARS) TrialR01NS132437 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI JAY L. ALBERTS · 2024 to 2026
$1.8M
Intramural NIH HHS ZIA AG000534NINDS NIH HHS R01 NS132437
6 · The paper itself

Abstract

Emerging evidence suggests that the genetic architecture of Alzheimer's (AD) and Parkinson's diseases (PD) risk varies across ancestries. This study seeks to explore distinct and universal genetic targets across individuals of Latino, African/African Admixed, East Asian, and European populations by implementing Population Attributable Risk (PAR) comparisons on summary statistics from genome-wide association studies (GWAS). PAR was calculated for the most significant disease variants using summary statistics derived from select multi-ancestry GWAS meta-analyses, followed by fine-mapping analysis to validate genetic contribution of disease variants to European, African/African Admixed, East Asian, and Latino individuals. For both AD,

Indexed as

Alzheimer’s diseaseclinical trialsgenetic riskgenome-wide associationheterogenous ancestriesParkinson’s diseasepopulation attributable risktarget prioritization

Identifiers

PMID39371162
PMCPMC11451675

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.