Evidence map›Paper›PMID 39371114›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Executive Function and Adherence in Children and Adolescents Living with HIV: Evidence from the HIV-associated Neurocognitive Disorders in Zambia (HANDZ) Study.

Sylvia Mwanza-Kabaghe, Kristen Sportiello, Mina Shah, Heather R Adams, Esau G Mbewe, Pelekelo P Kabundula, Colleen Schneider, Milimo Mweemba, Gretchen L Birbeck, David R Bearden

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Sylvia Mwanza-KabagheDepartment of Educational Psychology, University of Zambia, Lusaka, Zambia.
Kristen SportielloUniversity of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Mina ShahUniversity of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Heather R AdamsDivision of Child Neurology, Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA.
Esau G MbeweDepartment of Educational Psychology, University of Zambia, Lusaka, Zambia.
Pelekelo P KabundulaDepartment of Educational Psychology, University of Zambia, Lusaka, Zambia.
Colleen SchneiderUniversity of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Milimo MweembaUniversity Teaching Hospital Neurology Research Office, Lusaka, Zambia.
Gretchen L BirbeckDivision of Epilepsy, Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0002-0735-3461
David R BeardenDepartment of Educational Psychology, University of Zambia, Lusaka, Zambia.

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
Global Research Endeavors to Advance Treatment of Neurological Disorders in Africa (GREAT Neurology)R35NS122265 · NINDS · UNIVERSITY OF ROCHESTER · PI GRETCHEN L. BIRBECK · 2021 to 2026
$3.1M
Cohort of HIV-Associated Seizures and Epilepsy in Zambia (CHASE): Scale up and expansion informed by R21 FindingsR01NS094037 · NINDS · UNIVERSITY OF ROCHESTER · PI BIRBECK, GRETCHEN L., SIKAZWE, IZUKANJI · 2015 to 2019
$3.0M
Longitudinal Cognitive Outcomes in Children and Adolescents with HIV in ZambiaK23NS117310 · NINDS · UNIVERSITY OF ROCHESTER · PI BEARDEN, DAVID ROSS · 2020 to 2024
$1.0M
NIAID NIH HHS P30 AI045008NINDS NIH HHS K23 NS117310NINDS NIH HHS R01 NS094037NINDS NIH HHS R35 NS122265
6 · The paper itself

Abstract

Introduction: Executive function (EF) may be impaired in people with human immunodeficiency virus (HIV) infection, and poor EF may affect medication adherence. However, there is little data on EF in children with HIV in sub-Saharan Africa. Methods: 208 children/adolescents with perinatally acquired HIV and 208 HIV-exposed uninfected controls were recruited in Zambia for this prospective cohort study. EF was measured using performance-based, self-report, and parental report measures. Adherence over one year of follow-up was assessed through questionnaires and viral load measurement. Results: Children with HIV performed significantly worse on all three measures of EF. Lower parental rating of EF was associated with poorer antiretroviral therapy adherence (OR: 1.5, 95% CI = 1.02 - 2.2, p = 0.04). Conclusion: Children with HIV have EF impairments which may lead to consequences like poor medication adherence and treatment failure. Interventions to improve EF or compensate for impaired EF may be necessary in this population.

Indexed as

adherenceAfricachildrencognitive functionexecutive functionHIV

Identifiers

PMID39371114
PMCPMC11451720

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.