Evidence map›Paper›PMID 39370861›Full record

ArticleUltrasonography (Seoul, Korea)2024

Washout-parametric imaging with Sonazoid for enhanced differentiation of focal liver lesions.

Tatsuya Kakegawa, Katsutoshi Sugimoto, Naohisa Kamiyama, Hiroshi Hashimoto, Hiroshi Takahashi, Takuya Wada, Yu Yoshimasu, Hirohito Takeuchi, Ryohei Nakayama, Kentaro Sakamaki and 1 more

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Article in Ultrasonography (Seoul, Korea), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tatsuya KakegawaDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Katsutoshi SugimotoDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Naohisa KamiyamaUltrasound General Imaging, GE HealthCare, Tokyo, Japan.
Hiroshi HashimotoUltrasound General Imaging, GE HealthCare, Tokyo, Japan.
Hiroshi TakahashiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Takuya WadaDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Yu YoshimasuDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Hirohito TakeuchiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Ryohei NakayamaGraduate School of Science and Engineering, Ritsumeikan University, Shiga, Japan.
Kentaro SakamakiFaculty of Health Data Science, Juntendo University, Tokyo, Japan.
Takao ItoiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe study aimed to compare the diagnostic performance of washout-parametric imaging (WOPI) with that of conventional contrast-enhanced ultrasound (cCEUS) in differentiating focal liver lesions (FLLs).

methodsA total of 181 FLLs were imaged with contrast-enhanced ultrasound using Sonazoid, and the recordings were captured for 10 minutes in a prospective setting. WOPI was constructed from three images, depicting the arterial phase (peak enhancement), the early portal venous phase (1-minute post-injection), and the vasculo-Kupffer phase (5 or 10 minutes post-injection). The intensity variations in these images were color-coded and superimposed to produce a single image representing the washout timing across the lesions. From the 181 FLLs, 30 hepatocellular carcinomas (HCCs), 30 non-HCC malignancies, and 30 benign lesions were randomly selected for an observer study. Both techniques (cCEUS and WOPI) were evaluated by four off-site readers. They classified each lesion as benign or malignant using a continuous rating scale, with the endpoints representing "definitely benign" and "definitely malignant." The diagnostic performance of cCEUS and WOPI was compared using the area under the receiver operating characteristic curve (AUC) with the DeLong test. Interobserver agreement was assessed using the intraclass correlation coefficient (ICC).

resultsThe difference in average AUC values between WOPI and cCEUS was 0.0062 (95% confidence interval, -0.0161 to 0.0285), indicating no significant difference between techniques. The interobserver agreement was higher for WOPI (ICC, 0.77) than cCEUS (ICC, 0.67).

conclusionThe diagnostic performance of WOPI is comparable to that of cCEUS in differentiating FLLs, with superior interobserver agreement.

Indexed as

Contrast agentFocal liver lesionSonazoidUltrasonographyWashout parametric imaging

Identifiers

PMID39370861
PMCPMC11532521

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