Trial reportInternational dental journal2025
Effectiveness of Preprocedural Mouthwashes: A Triple-Blind Randomised Controlled Clinical Trial.
Trial report in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Antibacterial characteristics of black currant fruit extracts.BMC complementary medicine and therapies · 2026Article
- The Role of Saliva and Mouthwashes in the Detection and Reduction of Oral Viral Load: A Scoping Review.Viruses · 2025Article
- Microbiological and Ergonomic Effects of Three Prototypes of a Device to Reduce Aerosol Dispersion in Dental Care During the COVID-19 Pandemic: A Randomized Controlled Clinical Trial.Dentistry journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBioaerosols generated during dental treatment are considered to be potentially carriers of infectious respiratory pathogens. The use of preprocedural mouthwashes has been suggested to reduce microbial load prior to dental surgery procedures. However, limited evidence on the effectiveness of preprocedural mouthwashes regarding mitigating respiratory pathogens exists. The aim of this clinical trial is to determine and compare the effectiveness of 3 preprocedural mouthwashes recommended by the Department of Health of the Hong Kong Special Administrative Region in the mitigation of respiratory pathogens during dental care in pandemic times.
methodsIn all, 228 participants were block-randomised to three groups based on preprocedural mouthwash used: povidone-iodine, hydrogen peroxide, and chlorhexidine digluconate. Participants, operators, and assessors were blinded to the assigned mouthwashes (triple-blind). Saliva was assessed for the presence of a number of respiratory pathogens (19 viruses including SARS-CoV-2). Changes in the prevalence and mean number of "any" pathogen present following mouthwash use were determined.
resultsOverall, the prevalence of any detected respiratory viral pathogens in the preprocedural saliva was 3.5% as compared to the postprocedural saliva: 1.3% (P = .034). The mean (SD) number of viruses was significantly lower following preprocedural mouthwash use, from 0.04 (0.18) to 0.01 (0.11) (P = .025). No significant differences were observed in the downward change (∆) of any detected virus (prevalence) (P = .155) or in the reduction of the mean number (∆) of any detected virus in the postprocedural saliva compared to preprocedural saliva of participants with respect to mouthwash used (P = .375).
conclusionsThe practice of using preprocedural mouthwash, as recommended by the government of Hong Kong, was effective in reducing the number of respiratory pathogens present during dental aerosol-generating treatment. This study lends support for official policy on use of preprocedural mouthwashes, which has significant implications for practice and policy during pandemics.
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