Evidence map›Paper›PMID 39370254›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Critical Limb Threatening Ischemia Due to Severe Polyarteritis Nodosa.

Issei Yagi, Shusuke Yagi, Keisuke Nakanishi, Kazuki Tezuka, Kazuo Matsuyama, Yasushi Aibara, Takuya Ishida, Hiroto Yoneda, Masaki Yamamoto, Takayuki Ise and 7 more

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Issei YagiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Shusuke YagiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Keisuke NakanishiDepartment of Respiratory Medicine and Rheumatology, Tokushima University Hospital, Japan.
Kazuki TezukaDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Kazuo MatsuyamaShikoku Central Hospital of the Mutual Aid Association of Public School Teachers, Japan.
Yasushi AibaraShikoku Central Hospital of the Mutual Aid Association of Public School Teachers, Japan.
Takuya IshidaShikoku Central Hospital of the Mutual Aid Association of Public School Teachers, Japan.
Hiroto YonedaShikoku Central Hospital of the Mutual Aid Association of Public School Teachers, Japan.
Masaki YamamotoShikoku Central Hospital of the Mutual Aid Association of Public School Teachers, Japan.
Takayuki IseDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Koji YamaguchiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Hirotsugu YamadaDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Takeshi SoekiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Tetsuzo WakatsukiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Tetsuya KitagawaShikoku Central Hospital of the Mutual Aid Association of Public School Teachers, Japan.
Yasuhiko NishiokaDepartment of Respiratory Medicine and Rheumatology, Tokushima University Hospital, Japan.
Masataka SataDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A delayed diagnosis of polyarteritis nodosa may lead to critical limb-threatening ischemia (CLTI). A 74-year-old woman presented with left-foot pain and was treated with oral vasodilators and antiplatelet agents. However, the distal ischemia progressed to CLTI, including gangrene of the fingers and toes, and bilateral foot dropping appeared because of peroneal nerve paralysis. Angiography of the extremities revealed obstruction and stenosis of medium-sized arteries. Based on the progressive distal gangrene, mononeuropathy multiplex, and pathological findings of necrotic vasculitis, polyarteritis nodosa was diagnosed, and the patient's condition improved. A biopsy and neurological examination are essential for the appropriate diagnosis of PAN and immediate treatment.

Indexed as

IschemiaPolyarteritis NodosaAgedFemaleGangreneHumansSeverity of Illness Indexdigital gangrenemononeuropathy multiplexpolyarteritis nodosavasculitis

Identifiers

PMID39370254
PMCPMC12120210

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.