Evidence map›Paper›PMID 39369365›Full record

ArticleJournal of neuro-oncology2025

How well can simple clinical features predict long-term language recovery after left-hemisphere glioma surgery?

Irina Provlotskaya, Alina Minnigulova, Andrey Zyryanov, Mikhail Takmakov, Elizaveta Gordeyeva, Ekaterina Stupina, Galina Gunenko, Anton Kalinovskiy, Natalia Antonova, Anastasia Surova and 8 more

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Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Irina Provlotskaya *Center for Language and Brain, HSE University, 3 Krivokolenny Pereulok, 101000, Moscow, Russia. iprovlotskaya@hse.ru.
Alina Minnigulova *Center for Language and Brain, HSE University, 3 Krivokolenny Pereulok, 101000, Moscow, Russia.
Andrey Zyryanov *Center for Language and Brain, HSE University, 3 Krivokolenny Pereulok, 101000, Moscow, Russia.
Mikhail TakmakovCenter for Language and Brain, HSE University, 3 Krivokolenny Pereulok, 101000, Moscow, Russia.
Elizaveta GordeyevaDepartment of Neurology, National Medical and Surgical Center Named After N.I. Pirogov, 70 Nizhnyaya Pervomayskaya Ulitsa, Moscow, 105203, Russia.
Ekaterina StupinaCenter for Language and Brain, HSE University, 3 Krivokolenny Pereulok, 101000, Moscow, Russia.
Galina GunenkoDepartment of Neurooncology, Federal Center of Neurosurgery Novosibirsk, 132/1 Nemirovicha-Danchenko Ulitsa, Novosibirsk, 630048, Russia.
Anton KalinovskiyDepartment of Neurooncology, Federal Center of Neurosurgery Novosibirsk, 132/1 Nemirovicha-Danchenko Ulitsa, Novosibirsk, 630048, Russia.
Natalia AntonovaCenter for Language and Brain, HSE University, 25/12 Bolshaya Pecherskaya Ulitsa, Nizhny Novgorod, 603155, Russia.
Anastasia SurovaCenter for Language and Brain, HSE University, 25/12 Bolshaya Pecherskaya Ulitsa, Nizhny Novgorod, 603155, Russia.
Natalia GronskayaCenter for Language and Brain, HSE University, 25/12 Bolshaya Pecherskaya Ulitsa, Nizhny Novgorod, 603155, Russia.
Andrey ZuevDepartment of Neurosurgery, National Medical and Surgical Center Named After N.I. Pirogov, 70 Nizhnyaya Pervomayskaya Ulitsa, Moscow, 105203, Russia.
Nikita PedyashDepartment of Neurosurgery, National Medical and Surgical Center Named After N.I. Pirogov, 70 Nizhnyaya Pervomayskaya Ulitsa, Moscow, 105203, Russia.
Alexey DimertsevDepartment of Neurosurgery, National Medical and Surgical Center Named After N.I. Pirogov, 70 Nizhnyaya Pervomayskaya Ulitsa, Moscow, 105203, Russia.
Igor MedyanikDepartment of Neurosurgery, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 6030057, Russia.
Konstantin YashinDepartment of Neurosurgery, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 6030057, Russia.
Michail OstapyukDepartment of Neurosurgery, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 6030057, Russia.
Olga DragoyCenter for Language and Brain, HSE University, 3 Krivokolenny Pereulok, 101000, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLong-term language recovery after left-hemisphere glioma surgery varies substantially across patients. We investigated how well it can be predicted using clinical variables such as the postoperative decline in language processing, tumor grade, resection volume and location, extent of resection, and intraoperative language mapping. Beyond predicting the overall recovery, we examined which domains of language processing are most prone to persistent deficits.

methodsFifty-nine patients with left-hemisphere gliomas completed the Russian Aphasia Test (RAT) before surgery, immediately after surgery, and at follow-up three to seventeen months after surgery. We modeled their average language score (Generalized Aphasia Quotient, GAQ) at follow-up using a cross-validated multiple linear regression and calculated the number of patients showing persistent deficits in each subtest of the RAT.

resultsThe difference between GAQ scores at follow-up and before surgery was not significant at the group level but varied substantially across patients (mean -1.3%, range -34.2 - 9.2%). Our best-performing model predicted the follow-up GAQ scores with the mean absolute error of 3.5% (cross-validated R

conclusionThe postoperative decline in language processing and intraoperative language mapping explain a substantial amount of variability in long-term language recovery. Verbal working memory and lexical retrieval, particularly that of verbs, are most prone to persistent deficits.

Indexed as

Brain NeoplasmsGliomaRecovery of FunctionAdultAgedAphasiaFemaleFollow-Up StudiesFunctional LateralityHumansLanguageLanguage TestsMaleMiddle AgedNeurosurgical ProceduresPrognosisAphasia recoveryGliomaLanguage processingNeurosurgery

Identifiers

PMID39369365

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