Evidence map›Paper›PMID 39369298›Full record

ArticleAutophagy2024

SIGMAR1/Sigma-1 receptor: a key regulator in stabilizing and translating

Yu-Jie Chen, Jeffrey Knupp, Emily Wang, Peter Arvan, Billy Tsai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yu-Jie ChenDepartment of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
Jeffrey KnuppDepartment of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
Emily WangDepartment of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
Peter ArvanDivision of Metabolism Endocrinology & Diabetes, University of Michigan Medical School, Ann Arbor, MI, USA.
Billy TsaiDepartment of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0003-2859-1415

Funding

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Secretory Pathway Protein Degradation Maintains Insulin Biogenesis + SecretionR01DK111174 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARVAN, PETER, QI, LING · 2016 to 2024
$5.5M
How infectious SARS-CoV-2 exploits two ER membrane proteins to promote infectionR01AI170514 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Billy Tsai · 2022 to 2026
$1.9M
Investigating the role of ER-phagy in proinsulin quality controlF31DK128868 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KNUPP, JEFFREY RYAN · 2021 to 2023
$119k
NIAID NIH HHS R01 AI170514NIDDK NIH HHS F31 DK128868NIDDK NIH HHS R01 DK111174NIGMS NIH HHS T32 GM007315
6 · The paper itself

Abstract

Macroautophagy/autophagy degrades and recycles cellular constituents via the lysosome to maintain cellular homeostasis. Our study identified the endoplasmic reticulum (ER)-resident SIGMAR1 (sigma non-opioid intracellular receptor 1) as a critical regulator of the biosynthesis of Atg8-family proteins that leads to the lipidation that is essential during autophagosome formation. We demonstrate that SIGMAR1 stabilizes

Indexed as

AutophagosomesAutophagyEndoplasmic ReticulumMicrotubule-Associated ProteinsReceptors, sigmaRNA, MessengerSigma-1 Receptor3' Untranslated RegionsAdaptor Proteins, Signal TransducingAnimalsApoptosis Regulatory ProteinsAutophagy-Related Protein 8 FamilyHumansMiceProtein BiosynthesisRNA Stability3' Untranslated RegionsAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsAutophagy-Related Protein 8 FamilyMAP1LC3B protein, humanMicrotubule-Associated ProteinsReceptors, sigmaRNA, MessengerSigma-1 ReceptorATG8autophagyLC3lipidationlocalized translationSIGMAR1

Identifiers

PMID39369298
PMCPMC11587847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.