Evidence map›Paper›PMID 39369184›Full record

ArticleBMC oral health2024

Circulating mucosal-associated invariant T cell alterations in adults with recent-onset and long-term oral lichen planus.

Xiaoli Wu, Siting Chen, Yinshen Yang, Xiaoheng Xu, Xiaoqin Xiong, Wenxia Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoli Wu *Stomatological Hospital, School of Stomatology, Southern Medical University, S366 Jiangnan Boulevard, Haizhu District, Guangzhou City, Guangdong Province, 510280, P.R. China.
Siting Chen *Stomatological Hospital, School of Stomatology, Southern Medical University, S366 Jiangnan Boulevard, Haizhu District, Guangzhou City, Guangdong Province, 510280, P.R. China.
Yinshen YangStomatological Hospital, School of Stomatology, Southern Medical University, S366 Jiangnan Boulevard, Haizhu District, Guangzhou City, Guangdong Province, 510280, P.R. China.
Xiaoheng XuStomatological Hospital, School of Stomatology, Southern Medical University, S366 Jiangnan Boulevard, Haizhu District, Guangzhou City, Guangdong Province, 510280, P.R. China.
Xiaoqin XiongStomatological Hospital, School of Stomatology, Southern Medical University, S366 Jiangnan Boulevard, Haizhu District, Guangzhou City, Guangdong Province, 510280, P.R. China. 1183141018@qq.com.
Wenxia MengStomatological Hospital, School of Stomatology, Southern Medical University, S366 Jiangnan Boulevard, Haizhu District, Guangzhou City, Guangdong Province, 510280, P.R. China. mengwx2008@foxmail.com.ORCID http://orcid.org/0000-0003-2471-633X

Funding

Nonprofit Industry Research Specific Fund of National Health and Family Planning Commission of China 201502018Science research cultivation program of stomatological hospital, Southern medical university PY2022011
6 · The paper itself

Abstract

backgroundMucosal-associated invariant T (MAIT) cells play key roles in many inflammatory diseases. However, their effects on the long-term course of oral lichen planus (OLP) and recent-onset OLP remain unclear. In this study, we aimed to investigate the function of MAIT cells in the different processes of OLP and to explore the immunological background of this disease.

methodsThe frequency, phenotype, cytokine secretion, and clinical relevance of MAIT cells were investigated. MAIT cells were collected from the peripheral blood of 14 adults with recent-onset OLP (7-120 days after disease onset) and 16 adults with long-term course OLP (>2 years after diagnosis) using flow cytometry and compared with 15 healthy blood donors. Statistical analyses were performed using the GraphPad Prism software.

resultsMAIT cells from adults with recent-onset OLP exhibited an activated phenotype, as indicated by an increased frequency of CD69

conclusionsCirculating MAIT cells exhibited activation in OLP patients across varying disease durations. Given that PD-1 expression is elevated in adults with long-term OLP, it is reasonable to infer that circulating MAIT cells in long-term OLP may exhibit a more exhausted state than those in recent-onset OLP.

Indexed as

Lichen Planus, OralMucosal-Associated Invariant T CellsADP-ribosyl Cyclase 1AdultAgedAntigens, CDAntigens, Differentiation, T-LymphocyteCase-Control StudiesCD69 AntigensCytokinesFemaleFlow CytometryHumansInterleukin-17Lectins, C-TypeMaleADP-ribosyl Cyclase 1Antigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCytokinesInterleukin-17Lectins, C-TypePDCD1 protein, humanProgrammed Cell Death 1 ReceptorFunctional profileImmunoregulatory activityMucosal-associated invariant T cells (MAIT cells)Oral lichen planus (OLP)Phenotypes

Identifiers

PMID39369184
PMCPMC11453089

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.