ArticleSchizophrenia (Heidelberg, Germany)2024
Using machine learning to understand social isolation and loneliness in schizophrenia, bipolar disorder, and the community.
Article in Schizophrenia (Heidelberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Loneliness From the Digital Mental Health Practitioners' Perspective: Thematic Analysis of Semistructured Interviews.JMIR formative research · 2026Article
- Application of artificial intelligence in schizophrenia rehabilitation management: a systematic scoping review.Translational psychiatry · 2026Article
- Impact of early social isolation on social circuits and behavior: relevance to schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Predicting social isolation in maintenance hemodialysis patients using machine learning methods: a cross-sectional study.Frontiers in psychiatry · 2026Article
- Viewing social isolation as a complex dynamical system: A theoretical and computational framework.NPP - digital psychiatry and neuroscience · 2025Article
- The temporal relationships between social motivation and social interactions in people with serious mental illness and recent homelessness.Journal of mental health (Abingdon, England) · 2025Article
- Blunted Ventral Striatal Reactivity to Social Reward Is Associated with More Severe Motivation and Pleasure Deficits in Psychosis.Schizophrenia bulletin · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Social disconnection, including objective social isolation and subjective loneliness, is linked to substantial health risks. Yet, little is known about the predictors of social disconnection in individuals with mental illness. Here, we used machine learning to identify predictors of social isolation and loneliness in schizophrenia (N = 72), a psychiatric condition associated with social disconnection. For comparison, we also included two other groups: a psychiatric comparison sample of bipolar disorder (N = 48) and a community sample enriched for social isolation (N = 151). We fitted statistical models of social isolation and loneliness within and across groups. Each model included five candidate predictors: social avoidance motivation, depression, nonsocial cognition, social anhedonia, and social cognition. The results showed that social anhedonia explained unique variance in social isolation and loneliness in all samples, suggesting that it contributes to social isolation and loneliness broadly. However, nonsocial cognition explained unique variance in social isolation only within schizophrenia. Thus, social anhedonia could be a potential intervention target across populations, whereas nonsocial cognition may play a unique role in determining social disconnection in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.