Evidence map›Paper›PMID 39367984›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Oral toxicity assessment and the mitigation of lung carcinogenesis by phytol and α-bisabolol combination treatment in swiss albino mice: insights into redox enzyme modulation and caspase-dependent cell death mechanisms.

Chandramohan Kiruthiga, Sakthivel Jafni, Shankar Preethi, Namasivayam Rajesh Kannan, Kasi Pandima Devi

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chandramohan KiruthigaDepartment of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Sakthivel JafniDepartment of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Shankar PreethiDepartment of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Namasivayam Rajesh KannanDepartment of Psychiatry, Government Theni Medical College Hospital, Theni, Tamil Nadu, India.
Kasi Pandima DeviDepartment of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India. devikasi@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examined the safety and potential anti-lung cancer effects of combinations of phytol and α-bisabolol in Swiss albino mice. Both acute and subacute toxicity assessments showed that the combination of phytol and α-bisabolol is safe, with no adverse effects observed at higher concentrations. Hematological, biochemical, and histopathological tests showed no signs of toxicity in the heart, lungs, liver, spleen, and kidneys. The LD

Indexed as

Lung NeoplasmsPhytolSesquiterpenesAdministration, OralAnimalsAntioxidantsApoptosisCaspasesFemaleGlutathioneLungMaleMiceMonocyclic SesquiterpenesOxidation-ReductionOxidative StressAntioxidantsbisabololCaspasesGlutathioneMonocyclic SesquiterpenesPhytolProto-Oncogene Proteins c-bcl-2SesquiterpenesAcute toxicityBenzo(a)pyreneCombination therapyLung cancerPhytolSubacute toxicitySwiss albino miceTherapeutic efficacyα-Bisabolol

Identifiers

PMID39367984

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.