Evidence map›Paper›PMID 39367468›Full record

ReviewBMC oral health2024

Application of nanoparticles as surface modifiers of dental implants for revascularization/regeneration of bone.

Zar Chi Soe, Rahman Wahyudi, Nikos Mattheos, Attawood Lertpimonchai, Vincent Everts, Kevin A Tompkins, Thanaphum Osathanon, Chalida Nakalekha Limjeerajarus, Nuttapol Limjeerajarus

Abstract readReview
In one paragraph

Review in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zar Chi SoeFaculty of Dentistry, Graduate Program in Oral Biology, Chulalongkorn University, Bangkok, 10330, Thailand.
Rahman WahyudiFaculty of Dentistry, Graduate Program in Oral Biology, Chulalongkorn University, Bangkok, 10330, Thailand.
Nikos MattheosDepartment of Dental Medicine, Karolinska Institute, Stockholm, Sweden.
Attawood LertpimonchaiDepartment of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.
Vincent EvertsDepartment of Oral Cell Biology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands.
Kevin A TompkinsOffice of Research Affairs, Chulalongkorn University, Bangkok, 10330, Thailand.
Thanaphum OsathanonDepartment of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.
Chalida Nakalekha LimjeerajarusDepartment of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand. Chalida.N@chula.ac.th.
Nuttapol LimjeerajarusOffice of Research Affairs, Chulalongkorn University, Bangkok, 10330, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsseointegrated dental implants are widely established as a first-choice treatment for the replacement of missing teeth. Clinical outcomes are however often compromised by short or longer-term biological complications and pathologies. Nanoparticle-coated materials represent a very active research area with the potential to enhance clinical outcomes and reduce complications of implant therapy. This scoping review aimed to summarize current research on various types of nanoparticles (NPs) used as surface modifiers of dental implants and their potential to promote biological and clinical outcomes.

methodsA systematic electronic search was conducted in SCOPUS, PubMed and Google Scholar aiming to identify in vivo, in situ, or in vitro studies published between 2014 and 2024. Inclusion and exclusion criteria were determined and were described in the methods section.

resultsA total of 169 articles (44 original papers from Scopus and PubMed, and 125 articles from Google Scholar) were identified by the electronic search. Finally, 30 studies fit the inclusion criteria and were further used in this review. The findings from the selected papers suggest that nanoparticle-coated dental implants show promising results in enhancing bone regeneration and promoting angiogenesis around the implant site. These effects are due to the unique physicochemical properties of nanoparticle-coated implants and the controlled release of bioactive molecules from nanoparticle-modified surfaces.

conclusionNanoscale modifications displayed unique properties which could significantly enhance the properties of dental implants and further accelerate revascularization, and osseointegration while facilitating early implant loading. Yet, since many of these findings were based on in-vitro/in-situ systems, further research is required before such technology reaches clinical application.

Indexed as

Bone RegenerationDental ImplantsNanoparticlesSurface PropertiesCoated Materials, BiocompatibleDental Implantation, EndosseousHumansNeovascularization, PhysiologicOsseointegrationCoated Materials, BiocompatibleDental ImplantsBone remodellingBone vascularizationDental implantNanoparticlesSurface modification

Identifiers

PMID39367468
PMCPMC11451240

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.