Evidence map›Paper›PMID 39367452›Full record

Trial reportCritical care (London, England)2024

Phenotypes based on respiratory drive and effort to identify the risk factors when P0.1 fails to estimate ∆P

Meryl Vedrenne-Cloquet, Y Ito, J Hotz, M J Klein, M Herrera, D Chang, A K Bhalla, C J L Newth, R G Khemani

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03266016 nacompletednot on this map

Identifying and Preventing Ventilator Induced Diaphragm Dysfunction in Children

TypeinterventionalSponsorChildren's Hospital Los AngelesRan2017 to 2024Enrolled248ConditionsVentilation Therapy, Complications, Diaphragm Disease, Pediatric Respiratory DiseasesArmsComputerized Ventilator Protocol, Esophageal Manometry, Respiratory Inductance Plethysmography (RIP), Diaphragm Ultrasound, Maximal Inspiratory Pressure
NCT07323472 narecruitingnot on this mapstarted 2026, after this paper: background citation

Analysis of Respiratory Drive Activation, Ventilation, and Pulmonary Aeration Resulting From Body Lateralization in Critically Ill Patients Under Mechanical Ventilation

TypeinterventionalSponsorUniversity of PernambucoRan2026 to 2027Enrolled30ConditionsIntensive Care Units (ICUs)ArmsAutomatic Lateralization Therapy, Supine Positioning
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meryl Vedrenne-CloquetDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, USA. meryl_vedrenne@yahoo.fr.
Y ItoDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, USA.
J HotzDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, USA.
M J KleinDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, USA.
M HerreraDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, USA.
D ChangDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, USA.
A K BhallaDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, USA.
C J L NewthDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, USA.
R G KhemaniDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, USA.

Funding

Pathobiologic profile and outcomes of critically ill children and adolescents exposed to vaping and e-cigarettesR01HL134666 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KHEMANI, ROBINDER · 2017 to 2021
$3.3M
Patient Ventilator Asynchrony in Critically Ill ChildrenR01HL164397 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Robinder Khemani · 2023 to 2026
$2.8M
NHLBI NIH HHS R01 HL134666NHLBI NIH HHS R01 HL164397NIH HHS R01HL124666
6 · The paper itself

Abstract

backgroundMonitoring respiratory effort and drive during mechanical ventilation is needed to deliver lung and diaphragm protection. Esophageal pressure (∆P

methodsSecondary analysis of physiological data from children and young adults enrolled in a randomized controlled trial testing lung and diaphragm protective ventilation in pediatric acute respiratory distress syndrome (PARDS) (NCT03266016). ∆P

resultsWe analyzed 953 patient days (222 patients). ∆P

conclusionsIn patients with PARDS, P0.1 commonly underestimated high respiratory effort particularly with high airway resistance, high tidal volume, and high doses of opioids. Future studies are needed to investigate the impact of measures of respiratory effort, drive, and the presence of a mismatch phenotype on clinical outcome.

trial registrationNCT03266016; August 23, 2017.

Indexed as

PhenotypeRespiration, ArtificialAdolescentChildChild, PreschoolEsophagusFemaleHumansInfantMaleRespiratory Distress SyndromeRisk FactorsAirway occlusion pressureEsophageal pressureMechanical ventilationPediatric acute respiratory distress syndrome

Identifiers

PMID39367452
PMCPMC11453010

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.