Evidence map›Paper›PMID 39367288›Full record

ArticleJournal of general internal medicine2025

Out-of-Pocket Prescription Drug Savings for Medicare Beneficiaries with Asthma and COPD Under the Inflation Reduction Act.

Stephen A Mein, Archana Tale, Mary B Rice, Prihatha R Narasimmaraj, Rishi K Wadhera

Abstract read
In one paragraph

Article in Journal of general internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Exploring the Impact of Financial Toxicity in COPD: A Qualitative Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephen A MeinRichard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6567-1564
Archana TaleRichard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Mary B RiceDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Prihatha R NarasimmarajRichard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Rishi K WadheraRichard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. rwadhera@bidmc.harvard.edu.

Funding

Cardiovascular Health of Low-Income Working-Age Adults in the US: Health Care Access, Policy, and the PandemicR01HL164561 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Rishi Kumar Wadhera · 2022 to 2026
$3.7M
Training Program in Cardiovascular ResearchT32HL160522 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Jennifer E Ho · 2022 to 2026
$2.7M
Explaining Rising Heart Failure Mortality in MedicareK23HL148525 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WADHERA, RISHI KUMAR · 2019 to 2023
$863k
NHLBI NIH HHS 1T32HL160522-01A1NHLBI NIH HHS K23 HL148525NHLBI NIH HHS K23HL148525NHLBI NIH HHS R01 HL164561NHLBI NIH HHS R01HL164561NHLBI NIH HHS T32 HL160522
6 · The paper itself

Abstract

backgroundHigh and rising prescription drug costs for asthma and chronic obstructive pulmonary disease (COPD) contribute to medication nonadherence and poor clinical outcomes. The recently enacted Inflation Reduction Act includes provisions that will cap out-of-pocket prescription drug spending at $2,000 per year and expand low-income subsidies. However, little is known about how these provisions will impact out-of-pocket drug spending for Medicare beneficiaries with asthma and COPD.

objectiveTo estimate the impact of the Inflation Reduction Act's out-of-pocket spending cap and expansion of low-income subsidies on Medicare beneficiaries with obstructive lung disease.

designWe calculated the number of Medicare beneficiaries ≥ 65 years with asthma and/or COPD and out-of-pocket prescription drug spending > $2,000/year, and then estimated their median annual out-of-pocket savings under the Inflation Reduction Act's spending cap. We then estimated the number of beneficiaries with incomes > 135% and ≤ 150% of the federal poverty level who would become newly eligible for low-income subsidies under this policy.

participantsRespondents to the 2016-2019 Medical Expenditure Panel Survey (MEPS). MAIN MEASURES: Annual out-of-pocket prescription drug spending. KEY

resultsAn annual estimated 5.2 million Medicare beneficiaries had asthma and/or COPD. Among them, 360,160 (SE ± 38,021) experienced out-of-pocket drug spending > $2,000/year, with median out-of-pocket costs of $3,003/year (IQR $2,360-$3,941). Therefore, median savings under the Inflation Reduction Act's spending cap would be $1,003/year (IQR $360-$1,941), including $738/year and $1,137/year for beneficiaries with asthma and COPD, respectively. Total annual estimated savings would be $504 million (SE ± $42 M). In addition, 232,155 (SE ± 4,624) beneficiaries would newly qualify for low-income subsidies, which will further reduce prescription drug costs.

conclusionsThe Inflation Reduction Act will have major implications on out-of-pocket prescription drug spending for Medicare beneficiaries with obstructive lung disease resulting in half-a-billion dollars in total out-of-pocket savings per year, which could ultimately have implications on medication adherence and clinical outcomes.

Indexed as

AsthmaCost SavingsHealth ExpendituresMedicarePrescription DrugsPulmonary Disease, Chronic ObstructiveAgedAged, 80 and overDrug CostsFemaleFinancing, PersonalHumansMaleMedicare Part DUnited StatesPrescription Drugsasthmachronic obstructive pulmonary diseasehealth care costshealth policymedicare

Identifiers

PMID39367288
PMCPMC11968625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.