Evidence map›Paper›PMID 39367230›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

How enteral nutrition modes influence nasopharyngeal carcinoma survivors with late dysphagia after radiotherapy: a randomized controlled study.

Hongji Zeng, Weijia Zhao, Xuyang Zhang, Xin'ao Wang, Pengchao Luo, Heping Li, Liugen Wang, Xi Zeng

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06301763 (Oral Enteral Nutrition in Delayed Onset Radiotherapy-related Swallowing Disorder in Nasopharyngeal Carcinoma), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06301763 nacompletednot on this map

Oral Enteral Nutrition in Delayed Onset Radiotherapy-related Swallowing Disorder in Nasopharyngeal Carcinoma: A Randomly Controlled Study

TypeinterventionalSponsorMuhammadRan2023 to 2023Enrolled82ConditionsDysphagiaArmsIntermittent Oral-esophageal Tube Feeding, nasogastric tube feeding
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Review
  5. Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hongji ZengSchool of Public Health, Zhengzhou University, Zhengzhou, 450000, China.
Weijia ZhaoSchool of Public Health, Zhengzhou University, Zhengzhou, 450000, China.
Xuyang ZhangDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Xin'ao WangDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Pengchao LuoDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Heping LiDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Liugen WangDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China. wangliugenyouxiang@126.com.
Xi ZengDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China. zenghongjiclv@foxmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPalliation to late dysphagia after radiotherapy for nasopharyngeal carcinoma (NPC) continues to be a challenge. Intermittent oro-esophageal tube feeding (IOE) is an emerging enteral nutrition mode that can address nutrition and quality of life issues related to nasogastric tube feeding (NGT).

objectivesThis study aims to investigate the effect of IOE versus NGT in late dysphagia after radiotherapy for NPC.

methodsThis randomized controlled study included 82 NPC survivors with late dysphagia after radiotherapy. The subjects were randomized divided into the IOE and NGT groups (n1 = n2 = 41). Both groups received standard-of-care rehabilitation. Enteral nutrition supports were administered through IOE or NGT accordingly. This study lasted 2 weeks for each participant. The primary outcome was nutritional status including albumin, hemoglobin, total serum protein, and body mass index. The secondary outcomes were (i) the functional oral intake scale (FOIS), (ii) the penetration-aspiration scale (PAS), (iii) oral transit time (OTT), (iv) hyoid pause time (HPT), (v) pharyngeal transport time (PTT), and (vi) swallowing-quality of life (SWAL-QoL).

resultsThree cases quitted the study halfway and there were no significant baseline differences between the IOE (n = 40) and NGT (n = 39) groups. Both time and group effects were significant in all nutritional indicators. The time effect was significant in the FOIS levels, OTT and PTT, while the group effect was not. Either time or group effect were insignificant in the PAS levels and HPT. Both group and time effects were significant in the SWAL-QoL total scores (z

conclusionsRehabilitation interventions can improve swallowing function among NPC survivors with late dysphagia after radiotherapy. In this population who received standard-of-care rehabilitation, IOE is more conducive to the improvement of nutritional status, and swallowing-related quality of life.

trial registrationClinicalTrials.gov Identifier: NCT06301763.

Indexed as

Deglutition DisordersEnteral NutritionNasopharyngeal CarcinomaNasopharyngeal NeoplasmsQuality of LifeAdultAgedCancer SurvivorsFemaleHumansIntubation, GastrointestinalMaleMiddle AgedNutritional StatusCancersDysphagiaIntermittent oro-esophageal tube feedingQuality of life

Identifiers

PMID39367230

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.