Evidence map›Paper›PMID 39367221›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Risk factors associated with late-onset hearing loss in children with congenital cytomegalovirus: a systematic review.

María Fernández-Rueda, Christian Calvo-Henriquez, Rafael Fernández-Liesa, Alfredo García-Fernández, Roberto Pedrero-Tomé, Daniel Blázquez-Gamero, Joaquín De Vergas Guiterrez

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

María Fernández-RuedaDepartment of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario 12 Octubre, Avenida Córdoba S/N, 28041, Madrid, Spain. mfrueda29@gmail.com.ORCID http://orcid.org/0000-0002-4440-1864
Christian Calvo-HenriquezDepartment of Otorhinolaryngology-Head and Neck Surgery, Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0003-3580-0967
Rafael Fernández-LiesaDepartment of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario Miguel Servet, Saragossa, Spain.ORCID http://orcid.org/0000-0002-9678-1897
Alfredo García-FernándezDepartment of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario 12 Octubre, Avenida Córdoba S/N, 28041, Madrid, Spain.ORCID http://orcid.org/0000-0002-6019-1844
Roberto Pedrero-ToméResearch Institute Hospital 12 de Octubre (Imas12), Biomedical Foundation of the University Hospital 12 de Octubre (FBHU12O), Madrid, Spain.ORCID http://orcid.org/0000-0003-0318-2981
Daniel Blázquez-GameroPediatric Infectious Diseases Unit, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID http://orcid.org/0000-0001-6483-8329
Joaquín De Vergas GuiterrezDepartment of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario 12 Octubre, Avenida Córdoba S/N, 28041, Madrid, Spain.ORCID http://orcid.org/0000-0001-8384-4329

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo search for existing evidence of prognostic factors related to the development of late-onset hearing loss (LOHL) in infants with congenital cytomegalovirus (cCMV).

methodsA PRISMA systematic review was performed, with the PubMed, Embase, and Web of Science databases searched from inception through to December 2023; after the application of inclusion and exclusion criteria a total of 9 papers were included in this review. PROSPERO registration number CRD42024492244.

results9 studies encompassing a total of 292 children with late-onset hearing loss were included. A total of 12 risk factors were identified in the literature, with 6 found to be statistically significant. Late-onset hearing loss was more frequently reported in children with symptomatic than asymptomatic cCMV. Moreover, in asymptomatic cCMV cases, elevated DNAemia and salivary viral load were associated with late-onset hearing loss. Additionally, first-trimester seroconversion was identified as a risk factor for late- onset hearing loss. Further, gestational age < 37 weeks and low birth weight were found to correlate with late-onset hearing loss. Remarkably, only one study documented a relationship between late-onset hearing loss and ultrasonographic abnormalities.

conclusionsAlthough six statistically significant risk factors have been identified, the available evidence is limited and inconsistent, preventing the establishment of reliable neonatal and maternal parameters to predict the development of LOHL in patients with CMV. There are few studies addressing this topic, and those available exhibit a low level of evidence and heterogeneous designs. More studies should be done.

Indexed as

Cytomegalovirus InfectionsHearing LossAge of OnsetCytomegalovirusGestational AgeHumansInfantInfant, NewbornPregnancyRisk FactorsViral LoadCongenital cytomegalovirusHearing lossLate-onset hearing lossPrognosticatorsRisk factors

Identifiers

PMID39367221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.