Evidence map›Paper›PMID 39367213›Full record

ArticleJournal of nephrology2024

Urine epidermal growth factor as a biomarker for kidney function recovery and prognosis in glomerulonephritis with severe kidney function impairment.

Adriana Hernández-Andrade, Alberto Nordmann-Gomes, Bernardo Juárez-Cuevas, Maria Fernanda Zavala-Miranda, Cristino Cruz, Juan M Mejía-Vilet

Abstract read
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In one paragraph

Article in Journal of nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adriana Hernández-Andrade *Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Belisario Domínguez Sección XVI, Tlalpan, Mexico City, 14380, Mexico.ORCID 0009-0009-8566-0094
Alberto Nordmann-Gomes *Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Belisario Domínguez Sección XVI, Tlalpan, Mexico City, 14380, Mexico.ORCID 0009-0008-9763-8209
Bernardo Juárez-CuevasDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Belisario Domínguez Sección XVI, Tlalpan, Mexico City, 14380, Mexico.ORCID 0009-0005-3406-5448
Maria Fernanda Zavala-MirandaDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Belisario Domínguez Sección XVI, Tlalpan, Mexico City, 14380, Mexico.ORCID 0009-0006-9072-6957
Cristino CruzDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Belisario Domínguez Sección XVI, Tlalpan, Mexico City, 14380, Mexico.
Juan M Mejía-ViletDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Belisario Domínguez Sección XVI, Tlalpan, Mexico City, 14380, Mexico. juan.mejiav@incmnsz.mx.ORCID 0000-0003-4062-9412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrognostication in glomerulonephritis with severe kidney function impairment is critical for evaluating the benefit-to-risk ratio of immunosuppression. We hypothesized that the urine biomarker epidermal growth factor (EGF) could have good discrimination power to identify subjects who might ultimately recover kidney function.

methodsWe included 82 subjects with glomerulonephritis and severe kidney function impairment at admission (estimated glomerular filtration rate [eGFR] ≤ 30 mL/min/1.73m

resultsForty-four (54%) participants met the primary outcome of recovery of eGFR ≥ 30 mL/min/1.73m

conclusionsUrine EGF/Cr is a promising biomarker to aid in the prediction of recovery of kidney function in glomerulonephritis with severe kidney function impairment.

Indexed as

BiomarkersEpidermal Growth FactorGlomerular Filtration RateGlomerulonephritisKidneyRecovery of FunctionAdultAgedAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisCreatinineFemaleHumansLupus NephritisMaleMiddle AgedPredictive Value of TestsBiomarkersCreatinineEpidermal Growth FactorANCA vasculitisEpidermal growth factorGlomerulonephritisLupus nephritisuEGF/Cr

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.