Evidence map›Paper›PMID 39366933›Full record

ArticleNature communications2024

Tumor draining lymph nodes connected to cold triple-negative breast cancers are characterized by Th2-associated microenvironment.

Weihua Guo, Jiayi Tan, Lei Wang, Colt A Egelston, Diana L Simons, Aaron Ochoa, Min Hui Lim, Lu Wang, Shawn Solomon, James Waisman and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  9. CD169Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  11. Article
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  14. Article
  15. Article
  16. Review
  17. Article
  18. Nerves, nodes, and neoplasia.Frontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Weihua GuoDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID 0000-0002-9580-513X
Jiayi TanDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Lei WangDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Colt A EgelstonDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID 0000-0001-8440-1271
Diana L SimonsDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Aaron OchoaDepartment of Surgery, City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA.
Min Hui LimDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID 0009-0006-2790-8870
Lu WangMork Family Department of Chemical Engineering & Material Science, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0002-4136-8261
Shawn SolomonDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID 0000-0002-3819-9436
James WaismanDepartment of Medical Oncology, City of Hope, Duarte, CA, 91010, USA.
Christina H WeiDepartment of Pathology, City of Hope, Duarte, CA, 91010, USA.
Caroline HoffmannDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID 0000-0002-4430-3439
Joo SongDepartment of Pathology, City of Hope, Duarte, CA, 91010, USA.
Daniel SchmolzeDepartment of Pathology, City of Hope, Duarte, CA, 91010, USA.ORCID 0000-0002-6947-2546
Peter P LeeDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, USA. plee@coh.org.ORCID 0000-0002-2660-4377

Funding

Breast Cancer Research Foundation (BCRF) SU2C-BCRF 2015-001EIF | Stand Up To Cancer (SU2C) SU2C-BCRF 2015-001
6 · The paper itself

Abstract

Tumor draining lymph nodes (TDLN) represent a key component of the tumor-immunity cycle. There are few studies describing how TDLNs impact lymphocyte infiltration into tumors. Here we directly compare tumor-free TDLNs draining "cold" and "hot" human triple negative breast cancers (TDLN

Indexed as

Lymph NodesTh2 CellsTriple Negative Breast NeoplasmsTumor MicroenvironmentDendritic CellsFemaleGene Expression Regulation, NeoplasticHumansLymphocytes, Tumor-InfiltratingMast CellsTh1 Cells

Identifiers

PMID39366933
PMCPMC11452381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.