ArticleAJNR. American journal of neuroradiology2025
Super-Resolution in Clinically Available Spinal Cord MRIs Enables Automated Atrophy Analysis.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- MEASURING IMPACT OF SUPER-RESOLUTION ON SPINAL CORD MRI SCANS: LESION DETECTION SENSITIVITY, VARIABILITY, AND CLINICAL IMPACT.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025Article
- Neuroimaging phenotype characterization of early aggressive and late severe multiple sclerosis: a case-control study.Brain communications · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
background and purposeMeasurement of the mean upper cervical cord area (MUCCA) is an important biomarker in the study of neurodegeneration. However, dedicated high-resolution (HR) scans of the cervical spinal cord are rare in standard-of-care imaging due to timing and clinical usability. Most clinical cervical spinal cord imaging is sagittally acquired in 2D with thick slices and anisotropic voxels. As a solution, previous work describes HR T1-weighted brain imaging for measuring the upper cord area, but this is still not common in clinical care. MATERIALS AND
methodsWe propose using a zero-shot super-resolution technique, synthetic multi-orientation resolution enhancement (SMORE), already validated in the brain, to enhance the resolution of 2D-acquired scans for upper cord area calculations. To incorporate super-resolution in spinal cord analysis, we validate SMORE against HR research imaging and in a real-world longitudinal data analysis.
resultsSuper-resolved (SR) images reconstructed by using SMORE showed significantly greater similarity to the ground truth than low-resolution (LR) images across all tested resolutions (
conclusionsSuper-resolution is a valuable tool for enabling large-scale studies of cord atrophy, as LR images acquired in clinical practice are common and available.
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