Evidence map›Paper›PMID 39366762›Full record

ArticleLife science alliance2024

Epithelial-specific loss of Smad4 alleviates the fibrotic response in an acute colitis mouse model.

Zahra Hashemi, Thompson Hui, Alex Wu, Dahlia Matouba, Steven Zukowski, Shima Nejati, Crystal Lim, Julianna Bruzzese, Cindy Lin, Kyle Seabold and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zahra HashemiDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Thompson HuiDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Alex WuDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
Dahlia MatoubaDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Steven ZukowskiDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Shima NejatiDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Crystal LimDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Julianna BruzzeseDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.ORCID 0009-0004-2264-789X
Cindy LinDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Kyle SeaboldDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Connor MillsDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Kylee WrathDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Haoyu WangDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Hongjun WangDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Michael P VerziDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
Ansu PerekattDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA aperekat@stevens.edu.ORCID 0000-0003-3083-8405

Funding

Mechanisms Driving Metabolic Shifts in the Intestinal EpitheliumR01DK126446 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI VERZI, MICHAEL P. · 2021 to 2025
$2.1M
Transcriptional regulation of oncogenic cellular plasticity in the intestinal epitheliumK22CA218462 · NCI · THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY · PI PEREKATT, ANSU · 2018 to 2020
$486k
NCI NIH HHS K22 CA218462NIDDK NIH HHS R01 DK126446
6 · The paper itself

Abstract

Mucosal healing is associated with better clinical outcomes in patients with inflammatory bowel disease. But the epithelial-specific contribution to mucosal healing in vivo is poorly understood. We evaluated mucosal healing in an acute dextran sulfate sodium mouse model that shows an alleviated colitis response after epithelial-specific loss of Smad4. We find that enhanced epithelial wound healing alleviates the fibrotic response. Dextran sulfate sodium caused increased mesenchymal collagen deposition-indicative of fibrosis-within a week in the WT but not in the Smad4 KO colon. The fibrotic response correlated with decreased epithelial proliferation in the WT, whereas uninterrupted proliferation and an expanded zone of proliferation were observed in the Smad4 KO colon epithelium. Furthermore, the Smad4 KO colon showed epithelial extracellular matrix alterations that promote epithelial regeneration. Our data suggest that epithelium is a key determinant of the mucosal healing response in vivo, implicating mucosal healing as a strategy against fibrosis in inflammatory bowel disease patients.

Indexed as

ColitisDextran SulfateDisease Models, AnimalFibrosisIntestinal MucosaMice, KnockoutSmad4 ProteinWound HealingAnimalsCell ProliferationColonEpithelial CellsExtracellular MatrixMaleMiceMice, Inbred C57BLDextran SulfateSmad4 ProteinSmad4 protein, mouse

Identifiers

PMID39366762
PMCPMC11452480

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.