Evidence map›Paper›PMID 39366761›Full record

ArticleLife science alliance2024

Cholesterol promotes

Aurélie Hanin, Michela Comi, Tomokazu S Sumida, David A Hafler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aurélie HaninDepartments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-5912-9998
Michela ComiDepartments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Tomokazu S SumidaDepartments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
David A HaflerDepartments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, USA david.hafler@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 1985 to 2026
$85.0M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA016359NIH HHS S10 OD030363
6 · The paper itself

Abstract

IFNγ-secreting T cells are central for the maintenance of immune surveillance within the central nervous system (CNS). It was previously reported in healthy donors that the T-cell environment in the CNS induces distinct signatures related to cytotoxic capacity, CNS trafficking, tissue adaptation, and lipid homeostasis. These findings suggested that the CNS milieu consisting predominantly of lipids mediated the metabolic conditions leading to IFNγ-secreting brain CD4 T cells. Here, we demonstrate that the supplementation of CD4

Indexed as

CD4-Positive T-LymphocytesCholesterolImmediate-Early ProteinsInterferon-gammaProtein Serine-Threonine KinasesRNA, MessengerHumansMemory T CellsSerum-Glucocorticoid Regulated KinasesCholesterolIFNG protein, humanImmediate-Early ProteinsInterferon-gammaProtein Serine-Threonine KinasesRNA, MessengerSerum-Glucocorticoid Regulated Kinases

Identifiers

PMID39366761
PMCPMC11452476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.