Evidence map›Paper›PMID 39366703›Full record

ArticleGenome research2024

Genomic epidemiology of carbapenem-resistant Enterobacterales at a New York City hospital over a 10-year period reveals complex plasmid-clone dynamics and evidence for frequent horizontal transfer of

Angela Gomez-Simmonds, Medini K Annavajhala, Dwayne Seeram, Todd W Hokunson, Heekuk Park, Anne-Catrin Uhlemann

Abstract read
In one paragraph

Article in Genome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. A posttranslational modification of fimbriae drives pathogenicity inProceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Angela Gomez-SimmondsDivision of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, USA au2110@cumc.columbia.edu agomezsimmonds@ucdavis.edu.ORCID 0000-0001-5078-7137
Medini K AnnavajhalaDivision of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, USA.ORCID 0000-0002-9229-8849
Dwayne SeeramDivision of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, USA.
Todd W HokunsonDivision of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, USA.
Heekuk ParkDivision of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, USA.ORCID 0000-0001-5815-9717
Anne-Catrin UhlemannDivision of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, USA au2110@cumc.columbia.edu agomezsimmonds@ucdavis.edu.ORCID 0000-0002-9798-4768

Funding

Transcriptional Regulation of Urothelial Differentiation During Homeostasis and Repair in Response to Urinary Tract InfectionU54DK104309 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JONATHAN M. BARASCH, ALI G GHARAVI · 2014 to 2026
$17.7M
The Organoid and Cell Culture CoreP30DK132710 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert F. Schwabe · 2022 to 2026
$7.2M
Carbapenem-resistant bacterial colonization and infection after liver transplantR01AI116939 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI UHLEMANN, ANNE-CATRIN · 2015 to 2019
$2.4M
Genetic Factors associated with phenotypic beta-lactam resistance in extended-spectrum beta lactamase-producing EnterobacteralesR01AI175414 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Angela Gomez-Simmonds · 2024 to 2026
$1.4M
Elucidating transmission of plasmids harboring blaKPC among carbapenem-resistant Enterobacteriaceae using long-range sequencingK23AI137316 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOMEZ-SIMMONDS, ANGELA · 2019 to 2022
$779k
Mentoring program in patient-oriented research in microbial genomicsK24AI183182 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Anne-Catrin Uhlemann · 2024 to 2026
$606k
Delineating genetic determinants of polymyxin resistance in Serratia marcescensR21AI156727 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI UHLEMANN, ANNE-CATRIN · 2021 to 2022
$458k
Operationalizing wastewater-based surveillance of multidrug-resistant bacteriaK99AI163348 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANNAVAJHALA, MEDINI K · 2022 to 2023
$251k
NIAID NIH HHS K23 AI137316NIAID NIH HHS K24 AI183182NIAID NIH HHS K99 AI163348NIAID NIH HHS R01 AI116939NIAID NIH HHS R01 AI175414NIAID NIH HHS R21 AI156727NIDDK NIH HHS P30 DK132710NIDDK NIH HHS U54 DK104309
6 · The paper itself

Abstract

Transmission of carbapenem-resistant Enterobacterales (CRE) in hospitals has been shown to occur through complex, multifarious networks driven by both clonal spread and horizontal transfer mediated by plasmids and other mobile genetic elements. We performed nanopore long-read sequencing on CRE isolates from a large urban hospital system to determine the overall contribution of plasmids to CRE transmission and identify specific plasmids implicated in the spread of

Indexed as

Bacterial Proteinsbeta-LactamasesCarbapenemsGene Transfer, HorizontalPlasmidsAnti-Bacterial AgentsCarbapenem-Resistant EnterobacteriaceaeEnterobacteriaceae InfectionsHumansKlebsiella pneumoniaeMolecular EpidemiologyMultilocus Sequence TypingNew York CityPhylogenyAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenems

Identifiers

PMID39366703
PMCPMC11610580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.