Evidence map›Paper›PMID 39366659›Full record

SynthesisThe Thoracic and cardiovascular surgeon2025

Echocardiographic and Clinical Outcomes of Concomitant Secondary Chordal Cutting to Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy: A Systematic Review and Meta-analysis.

Tijn Julian Pieter Heeringa, Romy R M J J Hegeman, Len van Houwelingen, Marieke Hoogewerf, David Stecher, Johannes C Kelder, Pim van der Harst, Martin J Swaans, Mostafa M Mokhles, Ilonca Vaartjes and 2 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in The Thoracic and cardiovascular surgeon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tijn Julian Pieter HeeringaDepartment of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
Romy R M J J HegemanDepartment of Cardiothoracic Surgery, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.
Len van HouwelingenDepartment of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
Marieke HoogewerfDepartment of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
David StecherDepartment of Cardiothoracic Surgery, Medical Centre Leeuwarden, Leeuwarden, Fryslân, The Netherlands.
Johannes C KelderDepartment of Clinical Epidemiology, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.
Pim van der HarstDepartment of Cardiology, University Medical Centre Utrecht, Utrecht, Utrecht, The Netherlands.
Martin J SwaansDepartment of Cardiology, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.
Mostafa M MokhlesDepartment of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
Ilonca VaartjesDepartment of Cardiovascular Epidemiology, Julius Center for Health Sciences and Primary Care, Utrecht, Utrecht, The Netherlands.
Patrick KleinDepartment of Cardiothoracic Surgery, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.
Niels P van der KaaijDepartment of Cardiothoracic Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients who underwent surgical myectomy for hypertrophic obstructive cardiomyopathy (HOCM), additional mitral valve repair may offer additional benefits in terms of further reducing left ventricular outflow tract (LVOT) gradients, systolic anterior motion (SAM), and mitral regurgitation (MR). We performed a systematic review of the literature to evaluate the evidence of surgical myectomy with additional secondary chordal cutting in patients with HOCM. A systematic literature search in MEDLINE and EMBASE was performed until April 2024. The primary outcome studied was postoperative echocardiographic LVOT gradient. A random effects meta-analysis of means was performed for the primary outcome. The secondary outcomes studied were postoperative residual MR grade, 30-day new permanent pacemaker implantation, and in-hospital mortality. From 1,911 unique publications, a total of 6 articles fulfilled the inclusion criteria and comprised 471 patients with a pooled mean preoperative resting LVOT gradient of 84 mm Hg (95% confidence interval [CI]: 76-91). The postoperative pooled mean LVOT gradient was 11 mm Hg (95% CI: 10-12) with a low heterogeneity (

Indexed as

Cardiac Surgical ProceduresCardiomyopathy, HypertrophicChordae TendineaeEchocardiographyMitral ValveMitral Valve InsufficiencyVentricular Outflow ObstructionHospital MortalityHumansPredictive Value of TestsRecovery of FunctionRisk FactorsTime FactorsTreatment OutcomeVentricular Function, Left

Identifiers

PMID39366659
PMCPMC12503925

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.