Evidence map›Paper›PMID 39366503›Full record

ArticleEuropean journal of pharmacology2024

Impact of HIV-1 tat protein on methamphetamine-induced inhibition of vesicular monoamine transporter2-mediated dopamine transport and methamphetamine conditioned place preference in HIV-1 tat transgenic mice.

Jun Zhu, Abagail B Cirincione, Matthew J Strauss, Sarah E Davis, Shainnel O Eans, Danielle K Tribbitt, Nadine Alshakhshir, Jay P McLaughlin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. EcoHIV Infection Disrupts Dopamine and Serotonin Transporter Function, Altering Release Dynamics in C57BL/6J Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jun ZhuDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, 29208, USA. Electronic address: zhuj@cop.sc.edu.
Abagail B CirincioneDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, 29208, USA.
Matthew J StraussDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, 29208, USA.
Sarah E DavisDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, 29208, USA.
Shainnel O EansDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
Danielle K TribbittDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
Nadine AlshakhshirDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
Jay P McLaughlinDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.

Funding

Molecular mechanisms: Dysregulation of monoamine transporters by HIV-1Tat and cocaineR01DA035714 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Jay P. McLaughlin, CHANG-GUO ZHAN · 2013 to 2026
$6.6M
Allosteric Modulators of Dopamine Transporter as Therapeutic Agents for NeuroAIDSR01DA047924 · NIDA · SOUTHERN RESEARCH INSTITUTE · PI AUGELLI-SZAFRAN, CORINNE ELIZABETH, ZHU, JUN · 2020 to 2024
$4.3M
Impacts of morphine and HIV-Tat exposures and dimethylfumarate treatment on brain BDNF and mitochondrial and behavioral dysfunction.R01DA055568 · NIDA · UNIVERSITY OF FLORIDA · PI Marc J Kaufman, Jay P. McLaughlin · 2023 to 2026
$2.7M
Effects of HIV-1 Tat protein and methamphetamine on VMAT2-mediated dopamine transmission in the context of neuroHIV and drug abuseR01DA057866 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI CHANG-GUO ZHAN, Jun Zhu · 2023 to 2026
$2.6M
NIDA NIH HHS R01 DA035714NIDA NIH HHS R01 DA047924NIDA NIH HHS R01 DA055568NIDA NIH HHS R01 DA057866
6 · The paper itself

Abstract

Perturbation of dopamine transmission has been implicated as a contributing factor in HIV-1 associated neurocognitive disorders with concurrent methamphetamine (METH) abuse. We have demonstrated that the HIV-1 protein, transactivator of transcription (Tat), decreases dopamine transport through inhibition of vesicular monoamine transporter2 (VMAT2). This study determined the effects of Tat protein on METH-inhibited VMAT2 function and METH-conditioned place preference (CPP). In vitro exposure of isolated mouse whole brain vesicles to recombinant Tat

Indexed as

DopamineMethamphetamineMice, Transgenictat Gene Products, Human Immunodeficiency VirusVesicular Monoamine Transport ProteinsAnimalsBiological TransportConditioning, PsychologicalHIV-1MaleMiceMice, Inbred C57BLDopamineMethamphetamineSlc18a2 protein, mousetat Gene Products, Human Immunodeficiency VirusVesicular Monoamine Transport ProteinsConditioned place preferenceDopamineHIV-1 tat proteinMethamphetamineTetrabenazineUptakeVesicular monoamine transpoorter2

Identifiers

PMID39366503
PMCPMC11563864

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.