Evidence map›Paper›PMID 39366154›Full record

ArticleDrug and alcohol dependence2024

Factors associated with medications for opioid use disorder (MOUD) treatment success during the pregnancy and postpartum periods: A scoping review.

Maureen Mburu, Rita Masese, Elizabeth T Knippler, Melissa H Watt, Amnazo Muhirwa, Leila Ledbetter, Margaret Graton, Brandon A Knettel

Abstract readScoping Review
In one paragraph

Article in Drug and alcohol dependence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maureen MburuUniversity of Pittsburgh, Department of Medicine, Pittsburgh, PA 15261, USA.
Rita MaseseUniversity of North Carolina at Chapel Hill, School of Medicine, Department of Social Medicine, Chapel Hill, NC 27599, USA.
Elizabeth T KnipplerDuke University School of Nursing, 307 Trent Drive, Durham, NC 27710; Duke Center for AIDS Research, 200 Trent Dr, Durham, NC 27710.
Melissa H WattUniversity of Utah School of Medicine, Department of Population Health Sciences, 295 Chipeta Way, Salt Lake City, UT 84108, USA.
Amnazo MuhirwaDuke University School of Nursing, 307 Trent Drive, Durham, NC 27710.
Leila LedbetterDuke University Medical Center Library, Seeley G. Mudd Bldg, 103, Durham, NC 27710, USA.
Margaret GratonDuke University Medical Center Library, Seeley G. Mudd Bldg, 103, Durham, NC 27710, USA.
Brandon A KnettelDuke University School of Nursing, 307 Trent Drive, Durham, NC 27710; Duke Global Health Institute, 310 Trent Drive, Durham, NC 27710, USA; Duke Center for Global Mental Health, 310 Trent Drive, Durham, NC 27710, USA. Electronic address: Brandon.Knettel@duke.edu.

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
NIAID NIH HHS P30 AI064518
6 · The paper itself

Abstract

backgroundMedications for opioid use disorder (MOUD) are a crucial intervention for pregnant and postpartum individuals with opioid use disorder (OUD). However, there is paucity of data on the factors associated with MOUD treatment success in this population. This scoping review aimed to evaluate factors associated with MOUD success during the pregnancy and postpartum period.

methodsWe completed a structured search of MEDLINE, CINAHL, PsycINFO, Web of Science, and ProQuest databases. Eligible studies included a metric of success in outpatient treatment in the pregnancy and postpartum period and were conducted in the United States after the Food and Drug Administration's approval of buprenorphine in 2002. Reviewers independently screened studies for inclusion and extracted data. The primary outcome was treatment success (i.e., treatment adherence, abstinence from illicit opioids, or retention in care) during pregnancy and up to 12 months postpartum.

resultsData from 15 studies were included. Medications included methadone, naltrexone and buprenorphine (mono or combination therapy). High daily dose of buprenorphine as mono or combination therapy, early initiation and longer duration of MOUD were associated with treatment success. Legal involvement, homelessness, and rural residency were negatively associated with treatment success. There were no differences in outcomes of individuals receiving telemedicine versus in-person care.

conclusionWe identified several factors associated with MOUD treatment success among individuals with OUD during the pregnancy and postpartum periods. These factors may help guide future research and inform the development and adaptation of interventions tailored to better meet the needs of this key population.

Indexed as

BuprenorphineMethadoneOpiate Substitution TreatmentOpioid-Related DisordersPostpartum PeriodFemaleHumansNaltrexoneNarcotic AntagonistsPregnancyPregnancy ComplicationsTreatment OutcomeBuprenorphineMethadoneNaltrexoneNarcotic AntagonistsMedications for opioid use disorderOpioid use disorderPostpartumScoping review, pregnancyTreatment success

Identifiers

PMID39366154
PMCPMC12288043

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.