Evidence map›Paper›PMID 39365900›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Association of the Genetic Diversity of Killer Cell Immunoglobulin-like Receptor Genes and HLA-C Ligand in Saudi Women With Thyroid Cancer.

Razan A Altalhi, Ali Aljuaimlani, Mohammed Alswayyed, Maha Arafah, Yusra Tashkandy, Bader O Almutairi, Lamjed Mansour, Suliman Y Alomar

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Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Razan A AltalhiDepartment of Zoology, College of Science King Saud University, Riyadh, Saudi Arabia.ORCID 0009-0005-8510-8188
Ali AljuaimlaniDepartment of Zoology, College of Science King Saud University, Riyadh, Saudi Arabia.
Mohammed AlswayyedDepartment of Pathology and Laboratory Medicine, College of Science King Saud University, Riyadh, Saudi Arabia.
Maha ArafahDepartment of Pathology and Laboratory Medicine, College of Science King Saud University, Riyadh, Saudi Arabia.
Yusra TashkandyDepartment of Statistics and Operations Research, College of Science King Saud University, Riyadh, Saudi Arabia.
Bader O AlmutairiDepartment of Zoology, College of Science King Saud University, Riyadh, Saudi Arabia.
Lamjed MansourDepartment of Zoology, College of Science King Saud University, Riyadh, Saudi Arabia.
Suliman Y AlomarDepartment of Zoology, College of Science King Saud University, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGenetic diversity in the killer immunoglobulin-like receptor (KIR) gene composition and human leukocyte antigen (HLA) class I ligands, such as HLA-C, can affect the activity of natural killer cells and determine anti-cancer immunity. Specific

methodsIn this retrospective study, sixteen KIR genotypes and 2 HLA-C allotypes were determined using the polymerase chain reaction-sequence-specific primer (PCR-SSP) method, and the genotypes of 50 Saudi female patients with TC were compared with those of 50 Saudi female healthy controls (HC).

resultsWe observed a highly significant decrease in the presence of the

conclusionThese results suggest that the expression of KIR genes and their HLA-C ligands may influence the risk of TC development in Saudi women.

Indexed as

Genetic Predisposition to DiseaseGenotypeHLA-C AntigensReceptors, KIRThyroid NeoplasmsAdultCase-Control StudiesFemaleGenetic VariationHumansLigandsMiddle AgedPolymorphism, GeneticRetrospective StudiesSaudi ArabiaHLA-C AntigensKIR2DS2 protein, humanKIR2DS4 protein, humanLigandsReceptors, KIRgenetic associationHuman leukocyte AntigenKiller immunoglobulin-like receptorNatural Killer cellsthyroid cancer

Identifiers

PMID39365900
PMCPMC11452862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.