Evidence map›Paper›PMID 39365814›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Engineering substrate channeling in a bifunctional terpene synthase.

Eliott S Wenger, Kollin Schultz, Ronen Marmorstein, David W Christianson

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Crystal structure and catalytic mechanism of drimenol synthase, an unusual bifunctional terpene cyclase-phosphatase.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Eliott S WengerRoy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323.ORCID 0000-0001-6391-8036
Kollin SchultzAbramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-4456-8349
Ronen MarmorsteinAbramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-4373-4752
David W ChristiansonRoy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323.ORCID 0000-0002-0194-5212

Funding

STRUCTURE/FUNCTION OF BIOSYNTHETIC ENZYMESR01GM056838 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIANSON, DAVID W · 1998 to 2025
$8.0M
Molecular Mechanisms, Pathways and Inhibition of Acetyl-Transfer ReactionsR35GM118090 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ronen Marmorstein · 2016 to 2026
$6.7M
Predoctoral Training at the Chemistry-Biology InterfaceT32GM133398 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ronen Marmorstein, Ernest James Petersson · 2020 to 2026
$2.4M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01 GM56838NIGMS NIH HHS R01 GM056838NIGMS NIH HHS R35 GM118090NIGMS NIH HHS T32 GM133398
6 · The paper itself

Abstract

Fusicoccadiene synthase from

Indexed as

Alkyl and Aryl TransferasesCatalytic DomainDiterpenesPolyisoprenyl PhosphatesProtein EngineeringSubstrate SpecificityAlkyl and Aryl TransferasesDiterpenesgeranylgeranyl pyrophosphatePolyisoprenyl Phosphatesterpene synthasecryo-electron microscopyenzyme catalysisprotein engineering

Identifiers

PMID39365814
PMCPMC11474042

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.