Evidence map›Paper›PMID 39365674›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Nanoscale organization of cardiac calcium channels is dependent on thyroid hormone status.

Amanda Charest, Nicholas Nasta, Sumaiyah Siddiqui, Silvia Menkes, Anvin Thomas, Dana Saad, Jake Forman, Xueqi Huang, Cristina P Sison, A Martin Gerdes and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Amanda CharestDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, United States.
Nicholas NastaDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, United States.
Sumaiyah SiddiquiDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, United States.
Silvia MenkesDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, United States.
Anvin ThomasDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, United States.
Dana SaadDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, United States.
Jake FormanDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, United States.
Xueqi HuangBiostatistics Unit, Office of Academic Affairs, Northwell Health, New Hyde Park, New York, United States.ORCID 0009-0003-5664-3451
Cristina P SisonBiostatistics Unit, Office of Academic Affairs, Northwell Health, New Hyde Park, New York, United States.
A Martin GerdesDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, United States.ORCID 0000-0001-7393-489X
Randy F StoutDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, United States.ORCID 0000-0003-2725-306X
Kaie OjamaaDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, United States.ORCID 0000-0002-0130-7456

Funding

Thyroid hormone regulation of cardiomyocyte T-tubule structureand functionR15HL154068 · NHLBI · NEW YORK INST OF TECHNOLOGY · PI OJAMAA, KAIE MARGAREETA · 2020 to 2020
$428k
HHS | National Institutes of Health (NIH) 1R15HL154068-01NHLBI NIH HHS R15 HL154068
6 · The paper itself

Abstract

Thyroid hormone dysfunction is frequently observed in patients with chronic illnesses including heart failure, which increases the risk of adverse events. This study examined the effects of thyroid hormones (THs) on cardiac transverse-tubule (TT) integrity, Ca

Indexed as

Calcium Channels, L-TypeCalcium SignalingMyocytes, CardiacRats, Sprague-DawleyRyanodine Receptor Calcium Release ChannelAnimalsExcitation Contraction CouplingFemaleMembrane ProteinsPropylthiouracilRatsThyroid HormonesTriiodothyronineCacna1c protein, ratCalcium Channels, L-TypejunctophilinMembrane ProteinsPropylthiouracilRyanodine Receptor Calcium Release ChannelRyR2 protein, ratThyroid HormonesTriiodothyroninejunctophilin-2L-type calcium channelryanodine receptor-2STORMthyroid

Identifiers

PMID39365674
PMCPMC11559645

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.