Evidence map›Paper›PMID 39365609›Full record

ReviewMicrobial biotechnology2024

Engineering bacterial biocatalysts for the degradation of phthalic acid esters.

Gonzalo Durante-Rodríguez, Sofía de Francisco-Polanco, Unai Fernández-Arévalo, Eduardo Díaz

Abstract readReview
In one paragraph

Review in Microbial biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gonzalo Durante-RodríguezDepartment of Biotechnology, Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Spain.
Sofía de Francisco-PolancoDepartment of Biotechnology, Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Spain.
Unai Fernández-ArévaloDepartment of Biotechnology, Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Spain.
Eduardo DíazDepartment of Biotechnology, Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Spain.ORCID 0000-0002-9731-6524

Funding

European Commission 101000733Ministerio de Ciencia, Innovación y Universidades MICIU/AEI/10.13039/501100011033Ministerio de Ciencia, Innovación y Universidades PID2019-110612RB-I00Ministerio de Ciencia, Innovación y Universidades PID2022-142540OB-I00Ministerio de Ciencia, Innovación y Universidades TED2021-132135B-I00
6 · The paper itself

Abstract

Phthalic acid esters (PAEs) are synthetic diesters derived from o-phthalic acid, commonly used as plasticizers. These compounds pose significant environmental and health risks due to their ability to leach into the environment and act as endocrine disruptors, carcinogens, and mutagens. Consequently, PAEs are now considered major emerging contaminants and priority pollutants. Microbial degradation, primarily by bacteria and fungi, offers a promising method for PAEs bioremediation. This article highlights the current state of microbial PAEs degradation, focusing on the major bottlenecks and associated challenges. These include the identification of novel and more efficient PAE hydrolases to address the complexity of PAE mixtures in the environment, understanding PAEs uptake mechanisms, characterizing novel o-phthalate degradation pathways, and studying the regulatory network that controls the expression of PAE degradation genes. Future research directions include mitigating the impact of PAEs on health and ecosystems, developing biosensors for monitoring and measuring bioavailable PAEs concentrations, and valorizing these residues into other products of industrial interest, among others.

Indexed as

BacteriaBiodegradation, EnvironmentalEstersPhthalic AcidsEnvironmental PollutantsHydrolasesMetabolic EngineeringEnvironmental PollutantsEstersHydrolasesphthalic acidPhthalic Acids

Identifiers

PMID39365609
PMCPMC11451385

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.