Evidence map›Paper›PMID 39365526›Full record

SynthesisClinical and experimental nephrology2025

Utility of ultrasound in measuring quadriceps muscle thickness in patients receiving maintenance hemodialysis: comprehensive systematic review and meta-analysis.

Anas Elgenidy, Shady Sapoor, Hasnaa Abdelrhem, Ahmed Said Ali, Saif Sulliman, Sohieb Hedawy, Ayman Elgharori, Hassaan Mady, Wisam Abraheem Hasan, Mohamed Nasser and 4 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anas Elgenidy *Department of Neurology, Faculty of Medicine, Cairo University, Cairo, Egypt. Anas.elgenidy@gmail.com.ORCID http://orcid.org/0000-0002-4532-8574
Shady Sapoor *Faculty of Medicine, Benha University, Benha, Egypt.
Hasnaa AbdelrhemFaculty of Science, Cairo University, Cairo, Egypt.
Ahmed Said AliDepartment of Neurology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Saif SullimanFaculty of Medicine, Cairo, Egypt.
Sohieb HedawyFaculty of Medicine, Al-Azhar Assiut University, Assiut, Egypt.
Ayman ElgharoriFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Hassaan MadyDepartment of Neurology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Wisam Abraheem HasanFaculty of Medicine, Omar Al-Mukhtar University, Bayda, Libya.
Mohamed NasserFaculty of Medicine, Minia University, Al Minya, Egypt.
Esraa Abd Elaal AttaFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Mohamed GhitaDepartment of Neurology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mostafa G AlyNephrology Section, Sana-Klinikum Hof, Hof, Germany.
Jana ZschüntzschDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMuscle wasting, a prevalent issue in hemodialysis patients, is effectively assessed by measuring quadriceps muscle thickness, a crucial health indicator. This meta-analysis integrates findings from various studies on the application of ultrasonography (US) for measuring the thickness of quadriceps muscles in patients undergoing maintenance hemodialysis. DESIGN AND

methodsWe conducted a thorough literature search across PubMed, Scopus, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science up to April 2023. The R software's Meta package was used for mean difference analysis of quadriceps rectus femoris thickness (QRFT) and quadriceps vastus intermedius thickness (QVIT) between hemodialysis patients and healthy controls. All of the patients entered the meta-analysis are Caucasians. Sub-group analyses based on measurement sites and pre- and post-dialysis comparisons were performed.

resultsAmong 15 studies with 1584 patients, a significant decrease in QRFT and QVIT was observed in hemodialysis patients compared to healthy controls (mean difference = 0.40 cm, 95% CI: -0.49 to -0.31 and 0.46 cm, respectively). Right and left QRFT were notably thinner in hemodialysis patients (RT: mean difference = 0.39 cm; LT: mean difference = 0.42 cm). Similarly, right and left QVIT were notably thinner in hemodialysis patients (RT: mean difference = 0.45 cm; LT: mean difference = 0.47 cm). No significant pre- and post-dialysis QRFT differences were found.

conclusionUltrasonography is a reliable, accessible tool for assessing quadriceps muscle thickness in hemodialysis patients, revealing consistent muscle thickness reduction. These findings emphasize the need for routine muscle health monitoring in this population and support ultrasound use for regular assessments.

Indexed as

Muscular AtrophyQuadriceps MuscleRenal DialysisHumansMalePredictive Value of TestsUltrasonographyHemodialysisMuscle thicknessQuadriceps muscleSystematic review and meta-analysisUltrasound

Identifiers

PMID39365526

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.