Evidence map›Paper›PMID 39365383›Full record

ArticleIntensive care medicine experimental2024

Estimation of transpulmonary driving pressure using a lower assist maneuver (LAM) during synchronized ventilation in patients with acute respiratory failure: a physiological study.

Ling Liu, Hao He, Meihao Liang, Jennifer Beck, Christer Sinderby

Registry-linked trialAbstract read
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In one paragraph

Article in Intensive care medicine experimental, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05378802 (Comparison of Spontaneous Breathing and Controlled Ventilation), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05378802 nacompletednot on this map

Comparison of Spontaneous Breathing and Controlled Ventilation

TypeinterventionalSponsorSoutheast University, ChinaRan2021 to 2023Enrolled10ConditionsAcute Respiratory FailureArmsdifferent modes of mechanical ventilation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ling LiuJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
Hao HeJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
Meihao LiangJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
Jennifer BeckDepartment of Critical Care, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B1W8, Canada. jennifer.beck@rogers.com.ORCID http://orcid.org/0000-0002-5969-4647
Christer SinderbyDepartment of Critical Care, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B1W8, Canada.

Funding

"333 Project" of Jiangsu Province LGY2022025Key Technologies Research and Development Program 2022YFC2504405National Natural Science Foundation of China 82270083National Natural Science Foundation of China 82341032
6 · The paper itself

Abstract

backgroundWe previously showed in animals that transpulmonary driving pressure (PL) can be estimated during Neurally Adjusted Ventilatory Assist (NAVA) and Neural Pressure Support (NPS) using a single lower assist maneuver (LAM). The aim of this study was to test the LAM-based estimate of PL (PL_LAM) in patients with acute respiratory failure.

methodsThis was a prospective, physiological, and interventional study in intubated patients with acute respiratory failure. During both NAVA and simulated NPS (high and low levels of assist), a LAM was performed every 3 min by manually reducing the assist to zero for one single breath (by default, ventilator still provides 2 cmH

resultsTen patients were included in the study. For the group, PL_LAM was closely similar to PL_CMV, with a high correlation (R

conclusionThis physiological study in patients confirms our previous pre-clinical data that PL_LAM is as good an estimate as PL_Pes to determine PL, in spontaneously breathing patients on assisted mechanical ventilation. Trial registration The study was registered at clinicaltrials.gov (ID NCT05378802) on November 6, 2021.

Indexed as

Diaphragm electrical activityLower assist maneuverNeurally Adjusted Ventilatory AssistSimulated Neural Pressure SupportTranspulmonary pressure

Identifiers

PMID39365383
PMCPMC11452363

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