Evidence map›Paper›PMID 39365013›Full record

ArticleJournal of Crohn's & colitis2025

The Circulating Methylome in Childhood-Onset Inflammatory Bowel Disease.

Alexandra Noble, Alex Adams, Jan Nowak, Guo Cheng, Komal Nayak, Aisling Quinn, Mark Kristiansen, Rahul Kalla, Nicholas T Ventham, Federica Giachero and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Crohn's & colitis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Alexandra NobleTranslational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK.
Alex AdamsTranslational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK.
Jan NowakDepartment of Paediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.ORCID 0000-0003-0953-2188
Guo ChengDepartment of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
Komal NayakDepartment of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Aisling QuinnTranslational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK.
Mark KristiansenUCL Genomics, Great Ormond Street Institute of Child Health, University College London, London, UK.
Rahul KallaMedical Research Council Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-3276-6751
Nicholas T VenthamInstitute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Federica GiacheroDepartment of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Chamara JayamanneDepartment of Paediatrics, John Radcliffe Hospital, Oxford University Hospital NHS Trust, Oxford, UK.
Richard HansenDepartment of Child Health, Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.ORCID 0000-0002-3944-6646
Georgina L HoldMicrobiome Research Centre, St George and Sutherland Clinical Campuses, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0001-7573-3397
Emad El-OmarMicrobiome Research Centre, St George and Sutherland Clinical Campuses, University of New South Wales, Sydney, New South Wales, Australia.
Nicholas M CroftBlizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-1519-6435
David WilsonDepartment of Paediatric Gastroenterology and Nutrition, Royal Hospital for Children and Young People, Edinburgh, UK.
R Mark BeattieDepartment of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
James J AshtonDepartment of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
Matthias ZilbauerDepartment of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Sarah EnnisDepartment of Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK.
Holm H UhligTranslational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-6111-7355
Jack SatsangiTranslational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK.

Funding

Action Medical Research GN2880Biomedical Research Centre, OxfordCCUKECECCOMedical Research Council (MRC)National Health Service (NHS)National Institute for Health and Care Research (NIHR)The Leona M. and Harry B. Helmsley Charitable Trust
6 · The paper itself

Abstract

backgroundThe genetic contribution to inflammatory bowel disease (IBD), encompassing both Crohn's disease (CD) and ulcerative colitis (UC), accounts for around 20% of disease variance, highlighting the need to characterize environmental and epigenetic influences. Recently, considerable progress has been made in characterizing the adult methylome in epigenome-wide association studies.

methodsWe report detailed analysis of the circulating methylome in 86 patients with childhood-onset CD and UC and 30 controls using the Illumina Infinium Human MethylationEPIC platform.

resultsWe derived and validated a 4-probe methylation biomarker (RPS6KA2, VMP1, CFI, and ARHGEF3), with specificity and high diagnostic accuracy for pediatric IBD in UK and North American cohorts (area under the curve: 0.90-0.94). Significant epigenetic age acceleration is present at diagnosis, with the greatest observed in CD patients. Cis-methylation quantitative trait loci (meQTL) analysis identifies genetic determinants underlying epigenetic alterations notably within the HLA 6p22.1-p21.33 region. Passive smoking exposure is associated with the development of UC rather than CD, contrary to previous findings.

conclusionsThese data provide new insights into epigenetic alterations in IBD and illustrate the reproducibility and translational potential of epigenome-wide association studies in complex diseases.

Indexed as

Colitis, UlcerativeCrohn DiseaseDNA MethylationEpigenomeAdolescentAge of OnsetBiomarkersCase-Control StudiesChildEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansMaleMembrane ProteinsQuantitative Trait LociBiomarkersMembrane ProteinsRho Guanine Nucleotide Exchange FactorsTobacco Smoke PollutiondiagnosticsDNA methylationIBDpaediatrics

Identifiers

PMID39365013
PMCPMC11945304

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.