Evidence map›Paper›PMID 39364882›Full record

ReviewPain practice : the official journal of World Institute of Pain2024

8. Herpes zoster and post herpetic neuralgia.

Elisabeth J M Adriaansen, Julien G Jacobs, Lisette M Vernooij, Albert J M van Wijck, Steven P Cohen, Frank J P M Huygen, Mienke Rijsdijk

Abstract readReview
In one paragraph

Review in Pain practice : the official journal of World Institute of Pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  12. [Effects of spinal cord stimulation implantation on heart rate variability in patients with postherpetic neuralgia].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elisabeth J M AdriaansenPain Clinic, Department of Anesthesiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0001-6186-8979
Julien G JacobsAnesthesiology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Lisette M VernooijPain Clinic, Department of Anesthesiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Albert J M van WijckPain Clinic, Department of Anesthesiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Steven P CohenAnesthesiology, Neurology, Physical Medicine & Rehabilitation and Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Frank J P M HuygenPain Clinic, Department of Anesthesiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Mienke RijsdijkPain Clinic, Department of Anesthesiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPatients suffering from postherpetic neuralgia (PHN) report unilateral chronic pain in one or more dermatomes after an acute herpes zoster (HZ) infection. The incidence of acute HZ ranges between three and five patients per 1000 person-years. In one out of four patients, acute HZ-related pain will transition into PHN. PHN can be very disabling for patients and reduce quality of life. Additionally, the treatment of PHN is characterized by high failure rates. The aim of this review is to give an update on the previous practical guideline published in 2011 and revised in 2015 (published in 2019) and to provide an overview of current interventional treatment options for HZ infection and PHN.

methodsThe literature on the diagnosis and treatment of HZ and PHN was systematically reviewed and summarized.

resultsThe most important treatment for acute HZ-related pain is antiviral therapy within 72 h of symptom onset. Additional symptomatic treatment options are analgesic drugs according to the WHO pain ladder, tricyclic antidepressants (eg, nortriptyline), and antiepileptic drugs (eg, gabapentin). If pain is not sufficiently reduced, interventional treatment such as an epidural injection with local anesthetics and corticosteroids or pulsed radiofrequency of the dorsal root ganglion (DRG) are options. Treatment for PHN is preferably transdermal capsaicin, lidocaine, or oral drugs such as antidepressants or antiepileptics.

conclusionsTreatment of acute HZ-related pain especially PHN is challenging. Besides the conventional treatment for PHN, interventional management is considered a new treatment option. PRF of DRG seems to be the most promising interventional management.

Indexed as

evidence‐based medicineherpes zosterneuropathic painpostherpetic neuralgia

Identifiers

PMID39364882
PMCPMC11683194

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.