Evidence map›Paper›PMID 39364612›Full record

ArticleJournal of computational biology : a journal of computational molecular cell biology2024

Protocol for Designing

Henry Childs, Nathan Guerin, Pei Zhou, Bruce R Donald

Abstract read
In one paragraph

Article in Journal of computational biology : a journal of computational molecular cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Henry ChildsDepartment of Chemistry, Duke University, Durham, North Carolina, USA.ORCID 0009-0000-7657-9926
Nathan GuerinDepartment of Computer Science, Duke University, Durham, North Carolina, USA.
Pei ZhouDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.
Bruce R DonaldDepartment of Chemistry, Duke University, Durham, North Carolina, USA.

Funding

Diversity Supplement: Computational and Experimental Studies of Protein Structure and DesignR35GM144042 · NIGMS · DUKE UNIVERSITY · PI Bruce R. Donald · 2022 to 2026
$3.2M
Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogensR01AI139216 · NIAID · DUKE UNIVERSITY · PI ZHOU, PEI · 2019 to 2022
$1.9M
NIAID NIH HHS R01 AI139216NIGMS NIH HHS R35 GM144042
6 · The paper itself

Abstract

D-peptides, the mirror image of canonical L-peptides, offer numerous biological advantages that make them effective therapeutics. This article details how to use DexDesign, the newest OSPREY-based algorithm, for designing these D-peptides

Indexed as

AlgorithmsPeptidesAmino Acid SequenceModels, MolecularProtein ConformationSoftwarePeptidesde novo peptide designD-peptidesOSPREYprotein:ligand bindingprotocol

Identifiers

PMID39364612
PMCPMC11698684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.