Evidence map›Paper›PMID 39364404›Full record

ArticleFrontiers in immunology2024

Intralesional gene expression profile of JAK-STAT signaling pathway and associated cytokines in

Shima Hadifar, Nasrin Masoudzadeh, Hossein Heydari, Vahid Mashayekhi Goyonlo, Mohammadali Kerachian, Maryam Daneshpazhooh, Ali Sadeghnia, Nasim Tootoonchi, Reza Erfanian Salim, Sima Rafati and 1 more

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Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shima Hadifar *Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran.
Nasrin Masoudzadeh *Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran.
Hossein HeydariDepartment of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran.
Vahid Mashayekhi GoyonloCutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammadali KerachianCutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Maryam DaneshpazhoohAutoimmune Bullous Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Ali SadeghniaSchool of Medicine, Razi Hospital, Tehran, Iran.
Nasim TootoonchiSchool of Medicine, Razi Hospital, Tehran, Iran.
Reza Erfanian SalimNoor Eye Hospital, Tehran, Iran.
Sima RafatiDepartment of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran.
Ali M HarandiDepartment of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases. However, the involvement of this pathway in human cutaneous leishmaniasis (CL) due to Methods: This study sought to investigate differential gene expression of several cytokines and their associated Results: Results showed that the gene expression levelsof both Th1 ( Conclusion: Our finding revealed dysregulation of cytokines and related

Indexed as

CytokinesJanus KinasesLeishmaniasis, CutaneousLeishmania tropicaSignal TransductionSTAT Transcription FactorsAdolescentAdultFemaleGene Expression ProfilingHumansMaleMiddle AgedTranscriptomeYoung AdultCytokinesJanus KinasesSTAT Transcription Factorscutaneous leishmaniasiscytokinesimmune checkpointsJAK-STAT signaling pathwayLeishmania tropica

Identifiers

PMID39364404
PMCPMC11446769

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.